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Executive Stock Options, Missed Earnings Targets and Earnings Management
This paper examines whether stock‐option grants explain missed earnings targets, including reported losses, earnings declines, and missed analysts' forecasts. Anecdotal evidence and surveys suggest
Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ
The hypothesis that mitochondrially targeted therapies may be beneficial in the treatment of diabetic nephropathy is supported and a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis is highlighted.
Should Intangible Investments Be Reported Separately or Commingled with Operating Expenses? New Evidence
Predictability of future earnings and stock returns improves when these outlays are distinguished from operating expenses, and benefits could accrue from reporting them separately.
ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
This chapter focuses on the role played by ROS during the development of ALI/ARDS, the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in theDevelopment of endothelial permeability, and potential therapies targeted at oxidative stress.
Mitochondria‐targeted ubiquinone (MitoQ) decreases ethanol‐dependent micro and macro hepatosteatosis
The antioxidant capacity of MitoQ is demonstrated in alleviating alcohol‐associated mitochondrial reactive oxygen species (ROS) and several downstream effects of ROS/RNS (reactive nitrogen species) production such as inhibiting protein nitration and protein aldehyde formation and specifically ROS‐dependent HIF1α stabilization.
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.
A critical role for mitochondria in the pathogenesis of sepsis that involves a previously unrecognized function of MKK3 in mitochondrial quality control is demonstrated and this mitochondrial pathway may help reveal new diagnostic markers and therapeutic targets against septis.
Explaining the Recent Failure of Value Investing
It is widely believed that the long-standing and highly popular value investing strategy—investing in low-valued stocks and selling short high-valued equities—lost its edge in the past 10-12 years.
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
The antifibrotic properties of TH are associated with protection of alveolar epithelial cells and restoration of mitochondrial function and that TH may thus represent a potential therapy for pulmonary fibrosis.