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Biochemical targets in filarial worms for selective antifilarial drug design
TLDR
This review highlights the research and development of rational antifilarial agents and discusses the pitfalls since the discovery of diethylcarbamazine, the only drug of choice for controlling filariasis, despite its adverse side effects. Expand
Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models
The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P < 0.01) in normal rats and shows around 17.7% (P < 0.01) and 17.1% fallExpand
Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent
Poonam Shukla, Mavurapu Satyanarayana, Prem C. Verma, Jaya Tiwari, Atma P. Dwivedi, Rohit Srivastava, Neha Rehuja, Swayam P. Srivastava, Sudeep Gautam, Akhilesh K. Tamrakar, Anil K. Dwivedi, Hari N.Expand
Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. and analysis of phytoconstituents.
TLDR
It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. Marsupium. Expand
Search for antihyperglycemic activity in few marine flora and fauna
TLDR
Activity profile of 30 marine flora/fauna evaluated in sucrose loaded rat model shows slight but insignificant lowering in the blood glucose post sucrose load in normal rats at 250 mg/kg body weight dose. Expand
Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats.
Hepatoprotective activity of 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one, an isostere of dimethyl ricinine, was evaluated in adult male albino rats intoxicated with carbon tetrachloride,Expand
New species of Stenella from India
TLDR
Three new species of Stenella, S. lantanae and S. buteae occurring on Heterophragma sp. Expand
ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY IN STEM OF JATROPHA GOSSYPIFOLIA L.
Objectives: The present study was carried out to investigate the antidiabetic and hypolipidemic efficacy of active fractions (chloroform fraction of 95 % ethanolic extract and butanol fraction ofExpand
Inhibition of Alpha-Glucosidase by Acacia nilotica Prevents Hyperglycemia along with Improvement of Diabetic Complications via Aldose Reductase Inhibition
TLDR
The results suggest that EEAN possess antihyperglycemic activity through inhibition of alpha-glucosidase along with antidiabetogenic effect on polyol pathway through aldose reductase inhibition. Expand
Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase
TLDR
The results suggest that EEA possesses antidiabetic effect associated with alpha-glucosidase and aldose reductase inhibition, and this effect is associated with hyperglycaemia and diabetic nephropathy. Expand
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