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Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.
One of the compounds synthesized showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
Naphthalimide derivatives with therapeutic characteristics: a patent review
The tricyclic planar ring system of naphthalimide restrains important pharmaceutical properties along with excellent fluorescent after proper substitution pattern, which can be further enhanced by introducing polar side chains and fusing functionalized heterocyclic rings with naphhalimide cores.
Re-evaluation of superficial fascia of anterior abdominal wall: a computed tomographic study
The membranous layer is present in whole of the anterior abdominal wall and it divides the superficial fascia into three layers: superficial fatty layer, intermediate membran Mous layer, and deep fatty layer.
2-Methoxy-N′-(morpholin-4-ylcarbonothioyl)benzohydrazide hemihydrate
In the title compound, C13H17N3O3S·0.5H2O, the morpholine ring adopts a chair conformation. The conformation of the mol­ecule is stabilized by intra­molecular N—H⋯O and N—H⋯S hydrogen bonds.
Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents.
Four series of structurally related β-lactams, 2,5-pyrrolidinediones, azaspirodecatrienediones and dihydropyrroloquinoxalinetriones (DPQT) could be useful for the development of anti-obesity candidate drugs.
An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes.
The photocatalytic method was found to be effective for the condensation of less reactive heterocyclic aldehydes with o-phenylenediamines and was successfully employed for accessing pharmaceutically important benzimidazoles.
Synthesis of Alkaloid-Mimicking Tricyclic Skeletons by Diastereo- and Regioselective Ugi/ipso-Cyclization/Aza-Michael Cascade Reaction in One-Pot.
A one-pot process has been developed for preparing alkaloid-like tricyclic skeletons by employing an Ugi reaction, an acid mediated ipso-cyclization and an aza-Michael addition. The transformation is
A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin.
A robust and efficient synthetic route to highly functionalized enantiopure 1,2,3,4-tetrahydroisoquinolines (THIQs) from Garner aldehyde is reported and the enantioselective synthesis of 2-azapodophyllotoxin was achieved with an overall yield of 35.4% using this synthetic route.
Asymmetric Synthesis of Functionalized 2,5‐Pyrrolidinediones and β‐Lactams through Diastereospecific Cycloisomerization/Rearrangement of Chiral Ethanolamine‐Derived Ugi Adducts
A series of ethanolamine-derived Ugi four-component-reaction adducts were subjected to a base-mediated cycloisomerization/rearrangement cascade to give functionalized 2,5-pyrrolidinediones in
Tankyrase inhibitors as therapeutic targets for cancer.
The current review covers the progress, mechanism and binding modes of recently known Tankyrase inhibitor and discusses the rational approaches that were used to identify the tankyrase inhibitors.