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An enantiospecific total synthesis of (-)-patchouli alcohol
An enantiospecific total synthesis of patchouli alcohol, starting from the readily available monoterpene (R)-carvone, has been accomplished. A tandem double Michael reaction-alkylation sequence andExpand
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Construction of spiro[5.5]undecanes containing a quaternary carbon atom adjacent to a spirocentre via an Ireland ester Claisen rearrangement and RCM reaction sequence. Total syntheses of
Starting from cyclohexanecarboxylic acid, a combination of an Ireland ester Claisen rearrangement and RCM reactions was exploited for an efficient construction of spiro[5.5]undecanes containing aExpand
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Enantioselective total synthesis and assignment of the absolute configuration of (+)-laurokamurene B
The first enantioselective total synthesis of the rearranged aromatic sesquiterpene (+)-laurokamurene B, isolated from the Chinese red algae Laurencia okamurai Yamada, has been accomplished startingExpand
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Total synthesis of (±)-β-chamigrene and (±)-laurencenone C via Ireland ester Claisen rearrangement and an intramolecular type II carbonyl ene reaction sequence
A combination of Ireland ester Claisen rearrangement and intramolecular type II carbonyl ene reactions were exploited for the total synthesis of chamigrenes containing a quaternary carbon atom nextExpand
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Application of microwave heating technique for rapid synthesis of γ,δ-unsaturated esters
The use of microwave heating technique for the acceleration of ortho ester Claisen rearrangement (a three step transformation) is described. Irradiation of a DMF solution of the allyl alcohol 5,Expand
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Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug
Shikimic acid, more commonly known by its anionic form, shikimate, is an important intermediate compound of the ‘shikimate pathway’ in plants and microorganisms1. It is the principal precursor forExpand
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Facile formation of chiral bicyclo[3.3.1]nonenes via regioselective cyclopropane cleavage of 1-methyltricyclo[4.3.0.02,9]nonan-8-ols
Abstract Generation of bicyclo[3.3.1]non-2-enes via a facile, regioselective homo-1,4-elimination reaction of either exo or endo 1-methyltricyclo[4.3.0.0 2,9 ]nonan-8-ols on treatment with pyridineExpand
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Enantiospecific first total synthesis of (+)-cis,anti,cis-3-hydroxy-1,8,12,12-tetramethyl-4-oxatricyclo[6.4.0.02,6]dodecan-9-yl senecioate, the optical antipode of a natural thapsane isolated from
The enantiospecific first total synthesis of 10-hydroxy-10,11-epoxythapsan-5-yl senecioate (+)-1f, the enantiomer of the natural thapsane isolated from Thapsia villosa var minor, has beenExpand
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A radical cyclisation based strategy to cuparenoids; synthesis of (±)-α-cuparenone, (±)-epilaurene and laurenes
Abstract Mercuric acetate catalysed one pot Claisen rearrangement of the cinnamyl alcohol 5 , generated the pent-4-enal 9 , which on homologation resulted the hex-5-enal 10 . Radical cyclisation ofExpand
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