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Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli.
Bacterial populations produce persisters, cells that neither grow nor die in the presence of bactericidal agents, and thus exhibit multidrug tolerance (MDT). The mechanisms of MDT and the nature ofExpand
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A new antibiotic kills pathogens without detectable resistance
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soilExpand
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Persister cells and tolerance to antimicrobials.
Bacterial populations produce persister cells that neither grow nor die in the presence of microbicidal antibiotics. Persisters are largely responsible for high levels of biofilm tolerance toExpand
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Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials.
Biofilms are considered to be highly resistant to antimicrobial agents. Strictly speaking, this is not the case-biofilms do not grow in the presence of antimicrobials any better than do planktonicExpand
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Quorum sensing and DNA release in bacterial biofilms.
The multicellular behavior of bacteria has been the subject of much recent interest. This behavior includes coordinated control of virulence, luminescence, competence and biofilm formation; each ofExpand
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GlpD and PlsB participate in persister cell formation in Escherichia coli.
Bacterial populations produce dormant persister cells that are resistant to killing by all antibiotics currently in use, a phenomenon known as multidrug tolerance (MDT). Persisters are phenotypicExpand
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Languishing antibiotic discovery and flourishing antibiotic resistance have prompted the development of alternative untapped sources for antibiotic discovery, including previously unculturedExpand
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Microbial Scout Hypothesis, Stochastic Exit from Dormancy, and the Nature of Slow Growers
ABSTRACT We recently proposed a scout model of the microbial life cycle (S. S. Epstein, Nature 457:1083, 2009), the central element of which is the hypothesis that dormant microbial cells wake upExpand
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In situ cultivation of previously uncultivable microorganisms using the ichip
Most microbial species remain uncultivated, and modifying artificial nutrient media brings only an incremental increase in cultivability. We reasoned that an alternative way to cultivate species withExpand
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