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Toxicity and mutagenic activity of some selected Nigerian plants.
The result justified the use of the first eight plants and Chenopodium ambrosioides in the management of cancer in south west Nigeria although they appear to be non-selective and their mode of action may be different from plant to plant.
Chemical composition, antimicrobial activity, proximate analysis and mineral content of the seed of Detarium senegalense JF Gmelin
The results show the nutritional value of the seeds of D. senegalense and justified its use in the traditional treatment of skin diseases and antimicrobial activity.
Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria
Phytochemical analysis revealed the presence of tannins, saponins, and phenolic compounds in all the three plants tested, which confirmed the antimalarial activity of three medicinal plants used in Nigerian folklore for the treatment of malaria infection.
Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).
The results suggest that the methanolic extract of Cyathula prostrata possesses anti-inflammatory and analgesic activities and this authenticates the use of the plant in the traditional treatment of ailments associated with inflammation and pain.
Cytotoxicity evaluation of selected Nigerian plants used in traditional cancer treatment
Sapium exhibited a greater cytotoxic activity than all the plants tested and this provides scientific evidence to support the traditional use of the plant, which is also comparable to the activity of the reference compound Cisplatin in the MCF-7 cell line.
Studies on the anti-inflammatory and anti-nociceptive properties of Blepharis maderaspatensis leaves
Blepharis maderaspatensis (L.) B. Heyne ex Roth, Acanthaceae, is a procumbent or scrambling perennial herb used traditionally for treatment of snakebites, wounds, edema and gout. The
Antiproliferative and apoptosis inducing activity of Markhamia tomentosa leaf extract on HeLa cells.
The ethanolic extract of Markhamia tomentosa induces G0/G1 in HeLa cells followed by induction of the intrinsic pathway of apoptosis, which results in cell death after 24h exposure to brine shrimp lethality test.
Cytotoxic activity of selected Nigerian plants.
Sapium ellipticum leaves showed activity comparable to the reference compound Cisplatin and greater cytotoxic activity than Combretum paniculatum, Celosia trigyna, Drymaria cordata, Cyathula achyranthoides and Cyathulas prostata.
Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract.
The findings suggest that the ethanolic leaf extract of Markhamia tomentosa possesses anti-inflammatory activity possibly mediated by histamine, which justifies the use of the plant in the preparation of ethno medicines used in the treatment of ailments associated with inflammation.
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
The results obtained from this work suggest that Justicia extensa has anticonvulsant activity and this supports the use of the plant traditionally in the treatment of convulsion.