Share This Author
Endocrine-disrupting chemicals: an Endocrine Society scientific statement.
The evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology is presented.
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.
- A. Soto, C. Sonnenschein, K. Chung, M. Fernández, N. Olea, F. O. Serrano
- BiologyEnvironmental health perspectives
- 1 October 1995
The aims of the work summarized in this paper were to validate the E-SCREEN assay, to screen a variety of chemicals present in the environment to identify those that may be causing reproductive effects in wildlife and humans, and to assess whether environmental estrogens may act cumulatively.
Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption.
- L. Vandenberg, M. Maffini, C. Sonnenschein, B. Rubin, A. Soto
- BiologyEndocrine reviews
- 1 February 2009
This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Developmental effects of endocrine-disrupting chemicals in wildlife and humans
Estrogenicity of resin-based composites and sealants used in dentistry.
- N. Olea, R. Pulgar, C. Sonnenschein
- Medicine, Materials ScienceEnvironmental health perspectives
- 1 March 1996
The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels.
- B. Rubin, M. Murray, D. Damassa, J. King, A. Soto
- Biology, MedicineEnvironmental health perspectives
- 1 July 2001
Data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.
Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.
The importance of developmental stage and the realization that exposure to a presumptive "safe" dose of chemical may impact a life stage when there is normally no endogenous hormone exposure are emphasized, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects.
The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells.
The E-screen test revealed that estrogenic chemicals may act cumulatively; when mixed together they induce estrogenic responses at concentrations lower than those required when each compound is administered alone.