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Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury.
Cyclooxygenase-2 (COX-2), a widely distributed enzyme, plays an important role in inflammation. We have studied the role of COX-2 in acute pancreatitis and pancreatitis-associated lung injury usingExpand
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Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.
Intrapancreatic activation of trypsinogen is believed to play a critical role in the initiation of acute pancreatitis, but mechanisms responsible for intrapancreatic trypsinogen activation duringExpand
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Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation.
Intra-acinar cell nuclear factor-kappaB (NF-kappaB) and trypsinogen activation are early events in secretagogue-induced acute pancreatitis. We have studied the relationship between NF-kappaB andExpand
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Water Immersion Stress Prevents Caerulein-induced Pancreatic Acinar Cell NF-κB Activation by Attenuating Caerulein-induced Intracellular Ca2+ Changes*
Prior stress ameliorates caerulein-induced pancreatitis in rats. NF-κB is a proinflammatory transcription factor activated during caerulein pancreatitis. However, the effects of prior stress onExpand
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Body weight reduction in rats by oral treatment with zinc plus cyclo‐(His‐Pro)
Background and purpose:  We have previously shown that treatment with zinc plus cyclo‐(His‐Pro) (CHP) significantly stimulated synthesis of the insulin degrading enzyme and lowered plasma insulin andExpand
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Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.
Intra-acinar cell activation of digestive enzyme zymogens including trypsinogen is generally believed to be an early and critical event in acute pancreatitis. We have found that theExpand
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Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats.
BACKGROUND & AIMS Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermalExpand
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Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment
Background Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similarExpand
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Prevention and Treatment of Obesity and Diabetes and their Related Complications
This review article evaluates the current knowledge in the prevention and treatment of diabetes and obesity. The relative abundance of food and lack of rigorous exercise common in modern life poseExpand
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Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini.
BACKGROUND & AIMS The present study was undertaken to evaluate the role of serine proteases in regulating digestive enzyme secretion in pancreatic acinar cells. METHODS Isolated acini wereExpand
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