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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have shown the tuberousExpand
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Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1
ABSTRACT The tuberous sclerosis tumor suppressors TSC1 and TSC2 regulate the mTOR pathway to control translation and cell growth in response to nutrient and growth factor stimuli. We have recentlyExpand
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Translation of Chloroplast psbA mRNA Is Modulated in the Light by Counteracting Oxidizing and Reducing Activities
ABSTRACT Light has been proposed to stimulate the translation ofChlamydomonas reinhardtii chloroplast psbA mRNA by activating a protein complex associated with the 5′ untranslated region of thisExpand
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FOXO-regulated transcription restricts overgrowth of Tsc mutant organs
FOXO is thought to function as a repressor of growth that is, in turn, inhibited by insulin signaling. However, inactivating mutations in Drosophila melanogaster FOXO result in viable flies of normalExpand
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