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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
TLDR
This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.
Mitochondrial dysfunction and oxidative stress in aging and cancer
TLDR
This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype and suggests that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes.
Important molecular genetic markers of colorectal cancer
TLDR
The present review discusses the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.
Molecular markers of paragangliomas/pheochromocytomas
TLDR
The present review contemplates the mutations associated with the development of pheochromocytomas/paragangliomas and their potential to serve as specific markers of these tumors and their progression.
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells
TLDR
It is demonstrated that simultaneous inactivation of HK1 and HK2 was sufficient to decrease proliferation and viability of melanoma and colorectal cancer cells and could be the key therapeutic targets for reducing aerobic glycolysis in examined cancers.
Pan-Cancer Analysis of TCGA Data Revealed Promising Reference Genes for qPCR Normalization
TLDR
A scoring system was developed that allowed us to reveal novel promising RGs for each examined cancer type and identify several “universal” pan-cancer RG candidates, including SF3A1, CIAO1, and SFRS4.
Identification, Expression Analysis, and Target Prediction of Flax Genotroph MicroRNAs Under Normal and Nutrient Stress Conditions
Cultivated flax (Linum usitatissimum L.) is an important plant valuable for industry. Some flax lines can undergo heritable phenotypic and genotypic changes (LIS-1 insertion being the most common) in
The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection
TLDR
Two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets.
Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer
TLDR
T tumor-specific expression of alternative spliced transcripts of seven genes involved in energy metabolism in colorectal cancer are identified and a set of mRNA isoforms that could be used for cancer diagnosis and development of treatment methods are suggested.
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