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Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction.
Amyloid-β (Aβ)-induced mitochondrial dysfunction may play a role in the onset and progression of Alzheimer's disease (AD). Therefore, therapeutics targeted to improve mitochondrial function could beExpand
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Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.
Eosinophils are multifunctional leukocytes that degrade and remodel tissue extracellular matrix through production of proteolytic enzymes, release of proinflammatory factors to initiate and propagateExpand
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Fundamental trade-offs between information flow in single cells and cellular populations
Significance The function of signal transduction networks is to detect changes in the extracellular environment and combine this with information on intracellular state and thereby control cell-fateExpand
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Resistance to Lyme disease in decorin-deficient mice.
Microbial adhesion to the host tissue represents an early, critical step in the pathogenesis of most infectious diseases. BORRELIA: burgdorferi, the causative agent of Lyme disease (LD), expressesExpand
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GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neurotrophic peptide. Here, we show that PACAP recruits Rap1 into caveolin-enriched membrane subdomains in PC12 cells and activatesExpand
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Algorithm Design and Analysis
Z is a subsequence of X if there exists a strictly increasing sequence 〈i1, i2, ..., ik〉 of indices of X such that for all j = 1, 2, k, we have xij = zj . Expand
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The slow cell death response when screening chemotherapeutic agents
PurposeTo examine the correlation between cell death and a common surrogate of death used in screening assays, we compared cell death responses to those obtained with the sulforhodamine B (SRB) cellExpand
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Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
In the current era of antiretroviral treatment, the prevalence of HIV-associated dementia is on the rise. Many past works have associated inflammation and neuronal loss with cognitive deficitsExpand
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The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
PRK2/PKNgamma is a Rho effector and a member of the protein kinase C superfamily of serine/threonine kinases. Here, we explore the structure-function relationship between various motifs in theExpand
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NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression
The arginine vasopressin 1b receptor (Avpr1b) plays an important role in social behaviors including aggression, social learning and memory. Genetic removal of Avpr1b from mouse models results inExpand
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