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Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group.
TLDR
In patients with cystic fibrosis, the administration of rhDNase reduced but did not eliminate exacerbations of respiratory symptoms, resulted in slight improvement in pulmonary function, and was well tolerated.
Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group.
TLDR
In a 24-week study of patients with cystic fibrosis, intermittent administration of inhaled tobramycin was well tolerated and improved pulmonary function, decreased the density of P. aeruginosa in sputum, and decreased the risk of hospitalization.
Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis.
TLDR
Genotypic and phenotypic changes in P. aeruginosa from oropharynx and bronchoalveolar lavage fluid in a cohort of 40 CF patients during the first 3 years of life suggest infection occurs early in CF and may be intermittent or undetectable by culture.
Chronic Lyme borreliosis in the laboratory mouse.
TLDR
The results indicate that immunocompetent mice sustain persistent infections and develop early acute joint and heart lesions that resolve and then recur intermittently.
Salmonella enterica Serovar Pullorum Persists in Splenic Macrophages and in the Reproductive Tract during Persistent, Disease-Free Carriage in Chickens
TLDR
It is demonstrated that the main site of carriage in the spleen is within macrophages, which raises interesting questions about the biology of Salmonella serovar Pullorum, including why there is an increase in bacterial numbers when birds become sexually mature and in particular how SalmoneLLA avoids clearance by macrophage and whether it modulates the immune system in other ways.
Temporal dynamics of the cellular, humoral and cytokine responses in chickens during primary and secondary infection with Salmonella enterica serovar Typhimurium
TLDR
A strong coordinated antigen-specific humoral and cellular immune response was temporally linked to resolution of the primary infection and may be interpreted as the trafficking of reactive T cells from the spleen to the gut.
In vivo studies with an "orphan" parvovirus of mice.
TLDR
The results implicate a role for urinary, fecal, and perhaps respiratory excretion of virus, depending on host genotype and route of virus exposure, and suggest that evaluation of pancreatic and immune function during acute infection is warranted.
Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype.
TLDR
The results indicate that the allotropic variants of minute virus of mice may be useful tools to dissect molecular mechanisms of parvovirus virulence, that the virulence of MVMi for neonatal mice does not reside in its lymphotropism, and that genetic susceptibility to lethal M VMi infection may result from overproduction of noninfectious virus products.
A virulent nonencapsulated Haemophilus influenzae.
Nontypeable Haemophilus influenzae strain INT1 was isolated from the blood of a young child with clinical signs of meningitis following acute otitis media. No immunologic or anatomic predisposition
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