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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
The crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR α-subunit, is presented and is relevant for the development of drugs against Alzheimer’s disease and nicotine addiction. Expand
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Expand
Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures
Atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABAA,GABAC, 5HT3 serotonin, and glycine receptors are presented. Expand
Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex
It is shown that nicotine exposure increases the threshold for synaptic spike-timing-dependent potentiation (STDP) in layer V pyramidal neurons of the mouse PFC. Expand
Differential Transport and Local Translation of Cytoskeletal, Injury-Response, and Neurodegeneration Protein mRNAs in Axons
Recent studies have begun to focus on the signals that regulate axonal protein synthesis and the functional significance of localized protein synthesis. However, identification of proteins that areExpand
Genomewide Association for Major Depressive Disorder: A possible role for the presynaptic protein Piccolo
A genome-wide association study of single nucleotide polymorphisms genotyped in 1738 MDD cases and 1802 controls selected to be at low liability for MDD found 11 signals localized to a 167 kb region overlapping the gene piccolo, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain. Expand
Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention
Findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance and completely restored the attentional deficit but did not affect impulsive and motivational behavior. Expand
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
A molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft is described, and a model for how they actively regulate cholinergic transmission between neurons in the central nervous system is proposed. Expand
Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
It is shown that retrieval of fear memory induces a biphasic temporal change in GluA2-containing AMPA-type glutamate receptor (AMPAR) membrane expression and synaptic strength in the mouse dorsal hippocampus, which allows plastic changes at the synaptic level that exerts an inhibitory constraint on memory strengthening. Expand
Insight in nAChR subtype selectivity from AChBP crystal structures.
The various efforts towards rationalizing subtype specificity in nicotinic receptor subtypes through the structural studies of acetylcholine binding protein-ligand complexes are presented. Expand