Share This Author
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
The crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR α-subunit, is presented and is relevant for the development of drugs against Alzheimer’s disease and nicotine addiction.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures
Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
A large genetic association sample is used to detect novel loci and gain insight into the pathways, tissue and cell types involved in insomnia complaints, identifying 202 loci implicating 956 genes through positional, expression quantitative trait loci, and chromatin mapping.
Differential Transport and Local Translation of Cytoskeletal, Injury-Response, and Neurodegeneration Protein mRNAs in Axons
Recent studies have begun to focus on the signals that regulate axonal protein synthesis and the functional significance of localized protein synthesis. However, identification of proteins that are…
Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
It is shown that retrieval of fear memory induces a biphasic temporal change in GluA2-containing AMPA-type glutamate receptor (AMPAR) membrane expression and synaptic strength in the mouse dorsal hippocampus, which allows plastic changes at the synaptic level that exerts an inhibitory constraint on memory strengthening.
Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling
It is demonstrated that RA induces a general neuronal differentiation program in SH-SY5Y cells and that these cells develop a predominantly mature DAergic-like neurotransmitter phenotype, characterized by increased dopamine levels together with a substantial suppression of other neurotransmitter phenotypes.
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
A molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft is described, and a model for how they actively regulate cholinergic transmission between neurons in the central nervous system is proposed.