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Regulation of cyclooxygenase expression in the kidney by dietary salt intake.
TLDR
Divergent regulation of COX-2 in cortex and medulla by dietary salt suggests that prostaglandins in different kidney regions serve different functions, with medullary production playing a role in promoting the excretion of salt and water in volume overload, whereas cortical prostag landins may protect glomerular circulation in volume depletion. Expand
Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.
TLDR
The finding that COx-2 is critically involved in macula densa control of renin secretion indicates that the COX-2-expressing epithelial cells in the tubuloglomerular contact area are a likely source of prostaglandins participating in the signaling pathway between the macul densa and renin-producing granular cells. Expand
Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt.
TLDR
Results suggest that ncNOS expression in macula densa cells is inversely regulated by salt intake, thus following the known response of the renin-angiotensin system to changes in salt balance. Expand
Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction.
TLDR
Studies were undertaken to assess expression of inducible cyclooxygenase (COX)-2 in bladder during fetal development and COX-1 andCOX-2 expression after outlet obstruction, finding that outlet obstruction stimulates COX -2 expression dramatically, reactivating a gene that is highly expressed during fetalDevelopment. Expand
Renin expression in COX-2-knockout mice on normal or low-salt diets.
TLDR
It is concluded that COX-2 in the tubulovascular contact region is a critical determinant of renin synthesis in granular cells under resting conditions and that it participates in the stimulation of ren in expression caused by a low-NaCl intake. Expand
Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney.
TLDR
It is concluded that PPAR and RXR isoforms are expressed in a nephron segment-specific manner, suggesting distinct functions, with PPARα being involved in energy metabolism through regulating ACS in PCT and withPPARγ being involved with modulating RMIC growth and differentiation. Expand
Expression of PTHrP, PTH/PTHrP receptor, and Ca(2+)-sensing receptor mRNAs along the rat nephron.
TLDR
The results suggest that the function of TAL and DCT cells, in addition to being affected by PTH, may be directly altered by extracellular divalent cations through RaKCaR and that PTHrP may act in the glomerulus and proximal tubule as an autocrine or paracrine regulator of hemodynamics and phosphate transport. Expand
Renin and renin mRNA in proximal tubules of the rat kidney.
TLDR
The absence of a stimulatory effect of CEI on proximal tubule renin gene expression suggests the operation of different intracellular signals in control of renin synthesis in the proximaltubule than in the vascular compartment. Expand
Distribution of mineralocorticoid and glucocorticoid receptor mRNA along the nephron.
TLDR
The distribution pattern of MR and GR mRNA is consistent with the distribution of adrenal corticosteroid function along the nephron, as determined by a competitive polymerase chain reaction (PCR) technique. Expand
Endothelin-1 mRNA in glomerular and epithelial cells of kidney.
TLDR
The data show thatET-1 mRNA is present in all nephron segments studied and that its expression may be dependent on the functional state of the kidney, consistent with the proposal that ET-1 modifies tubular function in an autocrine or paracrine fashion. Expand
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