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Engineered human carboxypeptidase B enzymes that hydrolyse hippuryl-L-glutamic acid: reversed-polarity mutants.
Variants of human pancreatic carboxypeptidase B prepared by site-directed mutagenesis of the human gene and expressed in the periplasm of Escherichia coli have the potential to be used in antibody-directed enzyme prodrug therapy of cancer. Expand
L-Sorbose phosphorylation in Escherichia coli K-12.
- A. Slater, M. C. Jones-Mortimer, H. Kornberg
- Biology, Medicine
- Biochimica et biophysica acta
- 20 August 1981
L-Sorbose is phosphorylated by Escherichia coli by two distinct Enzymes II of the phosphoenolpyruvate-dependent phosphotransferase system, but sorbose inhibits the growth of strains expressing either of these functions constitutively. Expand
G-quadruplex ligands mediate downregulation of DUX4 expression
- L. Ciszewski, Ngoc B Lu-Nguyen, +5 authors L. Popplewell
- Medicine, Biology
- Nucleic acids research
- 17 March 2020
It is demonstrated for the first time that GQs are present in the DUX4 locus and that the GQ interactive ligand reduces Dux4 expression suggesting potential role of G Qs in FSHD pathogenesis. Expand
MELANOPLEUROIDES DOMINICANUS, A NEW LYGAEINE GENUS AND SPECIES FROM THE DOMINICAN REPUBLIC (HETEROPTERA: LYGAEIDAE)
Melanopleuroides dominicanus is described from the Dominican Republic. Characteristics to separate it from similar taxa, genitalic drawings, and a brief discussion of its phylogenetic relationships… Expand
Biophysical studies of the interaction between high molecular weight kininogen and gC1q-R : initiating the contact pathway
- A. Slater
- 14 December 2017
The contact pathway is part of the coagulation pathway involved in haemosta- sis. It is responsible for the deposition of fibrin fibres during blood coagulation as well as the production of the… Expand
Taxonomic Notes on Lygaeinae from Australia and Neighboring Areas (Heteroptera: Lygaeidae)
- A. Slater
- 15 November 1978
The genus Montaltus Distant is synonymized with Astacops Boisduval, and most species of the Caenocoris complex are placed generically. Expand
Family Lygaeidae Schilling, 1829 (= Infericornes Amyot and Serville, 1843; Myodochidae Kirkaldy, 1899; Geocoridae Kirkaldy, 1902)
ASHLOCKOBIUS, A NEW GENUS OF MYODOCHINI FROM VENEZUELA (HEMIPTERA : LYGAEOIDEA : RHYPAROCHROMIDAE : MYODOCHINI)
A NEW SPECIES OF MYODOCHA (HEMIPTERA: LYGAEIDAE: RHYPAROCHROMINAE: MYODOCHINI) FROM THE WEST INDIES
- A. Slater
- 1 March 1998
Myodocha froeschneri n. sp. is described based on specimens from Dominican Republic, Haiti, and Jamaica.