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Factors Affecting Virus Photoinactivation by a Series of Phenothiazine Dyes
- S. Wagner, A. Skripchenko, D. Robinette, J. Foley, L. Cincotta
- Biology, ChemistryPhotochemistry and photobiology
- 1 March 1998
The high affinity of 1,9‐di‐methyymethylene blue for DNA and the dye's efficient singlet oxygen yield suggest viral nucleic acid as a potential target, which could explain the photosensitizer's ability to inactivate viruses without adversely affecting anuclete red cells.
Temperature cycling during platelet cold storage improves in vivo recovery and survival in healthy volunteers
Cold‐induced changes are reversible by warming and periodic rewarming during cold storage (temperature cycling [TC]) has been proposed to alleviate cold‐induced reduction in PLT circulation.
Maintenance of platelet in vitro properties during 7‐day storage in M‐sol with a 30‐hour interruption of agitation
- S. Wagner, A. Myrup, H. Awatefe, D. Thompson‐Montgomery, J. Hirayama, A. Skripchenko
- 27 August 2008
The use of buffer‐containing PLT additive solutions (ASs) may better preserve PLT quality during storage by maintaining PLT pH and other in vitro variables.
Investigation of bacterial inactivation in apheresis platelets with 24 or 30 hours between inoculation and inactivation
Blood Centre logistics, staffing and donor scheduling may be optimized if pathogen inactivation (PI) of platelets can be delayed until Day 1, but bacteria may rapidly grow during this time. This…
Evaluation of in vitro storage properties of prestorage pooled whole blood–derived platelets suspended in 100 percent plasma and treated with amotosalen and long‐wavelength ultraviolet light
This study investigated the in vitro PLT properties of amotosalen‐PCT of leukoreduced pools of PLTs prepared by the PRP method and suspended in 100 percent plasma.
The influence of simulated shipping conditions (24‐ or 30‐hr interruption of agitation) on the in vitro properties of apheresis platelets during 7‐day storage
- S. Wagner, R. Vassallo, A. Skripchenko, Mindy Einarson, S. Seetharaman, G. Moroff
- 1 June 2008
Platelet components undergo interruption of agitation during shipment to maintain quality of whole blood–derived PLT concentrates and data are not available for apheresis PLTs in 100’percent plasma.
Thiazole orange, a DNA‐binding photosensitizer with flexible structure, can inactivate pathogens in red blood cell suspensions while maintaining red cell storage properties
- A. Skripchenko, S. Wagner, D. Thompson‐Montgomery, H. Awatefe
- Medicine, BiologyTransfusion
- 1 February 2006
The RBC binding properties of thiazole orange (TO), a flexible nucleic acid intercalating cyanine dye that predominantly acts as a photosensitizer only when bound, were assessed along with its virucidal, bactericidal, and light‐induced hemolytic activities.
In vivo recovery and survival of red cells after photodynamic treatment with thiopyrylium and red light using a canine model
Thiopyrylium phototreatment does not negatively affect canine RBC in vivo recovery and is suggested to have robust inactivation capabilities against a broad spectrum of pathogens in the human red blood cell (RBC) suspensions.
Mitochondrial dysfunction of platelets stored in first‐ and second‐generation containers is, in part, associated with elevated carbon dioxide levels
- A. Skripchenko, A. Myrup, D. Thompson‐Montgomery, H. Awatefe, S. Wagner
- 1 February 2011
The aim of this study was to evaluate mitochondrial function of PLTs stored in first‐ and second‐generation bags with different gas permeabilities to determine whether these bags influence the retention of in vitro PLT parameters during storage.
An Inhibition of p38 Mitogen Activated Protein Kinase Delays the Platelet Storage Lesion
- A. Skripchenko, H. Awatefe, D. Thompson‐Montgomery, A. Myrup, A. Turgeon, S. Wagner
- MedicinePloS one
- 13 August 2013
Signaling through p38 MAPK, but not ERK, is associated with platelet deterioration during storage, and inhibition by VX-702 leads to better maintenance of all platelet in vitro storage parameters including platelet mitochondrial function.