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Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
TLDR
Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well. Expand
Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial
TLDR
Intravenous high-dose rhEPO is well tolerated in acute ischemic stroke and associated with an improvement in clinical outcome at 1 month, and analysis of covariance controlled for these two variables indicated thatrhEPO treatment was associated with a improvement in follow-up and outcome scales. Expand
Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
TLDR
The pronounced up-regulation of EPO/EPOR in human ischemic/hypoxic brains underlines their role as an endogenous neuroprotective system and suggests a novel therapeutic potential in cerebrovascular disease for EPO, a clinically well-characterized and safe compound. Expand
Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells.
TLDR
A potential role for EPO as a therapeutic molecule against predominantly apoptotic neuronal cell death in the context of glaucoma or neurodegenerative diseases is supported and the PI-3-K/Akt pathway is delineated as the predominant mediator of EPO neuroprotection in this in vivo paradigm of neuronal cellDeath. Expand
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood–brain barrier integrity
TLDR
The >10% overall seroprevalence of NMDAR-AB of both healthy individuals and patients is unexpectedly high, however, apparently depends on association with past or present perturbations of blood–brain barrier function. Expand
Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin
TLDR
It is concluded that in hippocampal neurons, Stat5 is not required for neuroprotection by EPO but is together with Akt essential for its neurotrophic activity. Expand
The Brain Erythropoietin System and its Potential for Therapeutic Exploitation in Brain Disease
TLDR
The safety profile and effectiveness of EPO in a wide variety of neurologic disease models make EPO a candidate compound for a potential first-line therapeutic for neurologic emergencies. Expand
Endothelins regulate astrocyte gap junctions in rat hippocampal slices
TLDR
The results demonstrate that Ets decrease the expression of phosphorylated Cx43 forms and are potent inhibitors of GJC, identifying Ets as potent endogenous inhibitory regulators of astrocyte networks. Expand
Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system
TLDR
The studies on EPO are assessed and, in particular, on its structural or functional variants in experimental models of nervous system disorders, and a short overview of the completed and ongoing clinical studies testing EPO as neuroprotective/neuroregenerative treatment option in neuropsychiatric disease is provided. Expand
Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level
TLDR
The data suggest that neurons in discrete areas vulnerable for selective neuronal death, and possibly the vascular endothelium, are target cells for ischemia-induced glial IL-1β production. Expand
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