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Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260.
- B. Mayes, E. Mcconnell, J. Moore
- Medicine, BiologyToxicological sciences : an official journal of…
Liver toxicity was distinctly more severe in females than in males, and the incidence of hepatocellular neoplasms was highly sex-dependent, differed between Aroclor mixtures and, for females, increased with dose and followed the general incidence pattern.
Therapeutic approaches to dermatotoxicity by sulfur mustard I. Modulation of sulfur mustard‐induced cutaneous injury in the mouse ear vesicant model † **
- R. Casillas, R. Kiser, J. A. Blank
- Biology, MedicineJournal of applied toxicology : JAT
- 1 December 2000
Prophylactic and treatment effects of pharmacological agents against HD‐induced skin injury in an in vivo model are demonstrated and support the continued use of the mouse ear vesicant model (MEVM) for evaluating medical countermeasures against HD.
Comparative Carcinogenicity in Sprague-Dawley Rats of the Polychlorinated Biphenyl Mixtures Aroclors 1016, 1242, 1254, and 1260
Liver toxicity was distinctly more severe in females than in males, and the incidence of hepatocellular neoplasms was highly sex-dependent (females > males), differed between Aroclor mixtures and, for females, increased with dose and followed the general incidence pattern.
Relationship of pharmacokinetics and drug distribution in tissue to increased safety of amphotericin B colloidal dispersion in dogs
- R. Fielding, A. Singer, L. H. Wang, S. Babbar, L. Guo
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 February 1992
Although ABCD increased concentrations of AmB in the reticuloendothelial system, increased toxicity was not observed in these organs, and ABCD was eightfold safer than m-AmB.
Acute neuropathology in soman poisoned rats.
The results indicate that soman, and possibly other similar organophosphate compounds, may produce significant irreversible damage to the central nervous system.
Cardiomyopathy in Soman and Sarin intoxicated rats.
13-week inhalation toxicity study of dimethylformamide (DMF) in cynomolgus monkeys.
Pulmonary Response to Intratracheally Instilled Silicon Nitride in Rats
An examination of the cell populations recovered from the lavaged lungs of rats exposed to quartz revealed an increase in polymorpho-nuclear leukocytes and macrophages, and a decrease in macrophage viability, when compared to saline-instilled controls.
Sulfur mustard‐induced skin burns in weanling swine evaluated clinically and histopathologically †
- F. Reid, J. Graham, N. Niemuth, A. Singer, S. J. Janny, J. B. Johnson
- MedicineJournal of applied toxicology : JAT
- 1 December 2000
Histopathological indicators and clinical observations used to evaluate wound severity, depth and degree of healing on days 2 and 8 for full‐skin‐thickness sulfur‐mustard (HD)‐induced burns in weanling swine showed good indicators of wound healing.
Toxicity of diethanolamine. 2. Drinking water and topical application exposures in B6C3F1 mice
- R. Melnick, J. Mahler, J. Bucher, M. Hejtmancik, A. Singer, R. Persing
- Medicine, BiologyJournal of applied toxicology : JAT
Exposure to diethanolamine caused dose‐dependent toxic effects in the liver, liver, kidney, heart, heart and skin, and a no‐observed‐adverse‐effect level (NOAEL) was not achieved for hepatocellular cytological alterations or for acanthosis in the skin.