A. Simopoulos

Publications375
h-index59
Citations27,002
Highly Influential Citations1,162
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  • Publications
  • Influence
The importance of the ratio of omega-6/omega-3 essential fatty acids.
  • A. Simopoulos
  • Medicine
    Biomedicine & pharmacotherapy = Biomedecine…
  • 1 October 2002
View on PubMed
The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases
  • A. Simopoulos
  • Medicine
    Experimental biology and medicine
  • 1 June 2008
TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries.
View on SAGE
Omega-3 fatty acids in health and disease and in growth and development.
  • A. Simopoulos
  • Medicine, Biology
    The American journal of clinical nutrition
  • 1 September 1991
TLDR
Omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors, which is essential for the normal functional development of the retina and brain, particularly in premature infants.
View on PubMed
Essential fatty acids in health and chronic disease.
  • A. Simopoulos
  • Medicine
    The American journal of clinical nutrition
  • 1 September 1999
TLDR
Alpha-linolenic acid, found in green leafy vegetables, flaxseed, rapeseed, and walnuts, desaturates and elongates in the human body to EPA and DHA and by itself may have beneficial effects in health and in the control of chronic diseases.
View on PubMed
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
  • A. Simopoulos
  • Medicine, Biology
    Journal of the American College of Nutrition
  • 1 December 2002
TLDR
Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases.
View on Taylor & Francis
Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.
  • A. Simopoulos
  • Medicine, Biology
    Biomedicine & pharmacotherapy = Biomedecine…
  • 1 November 2006
View on PubMed
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
TLDR
The omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eICosapentaenoic acid (EPA) and docosahexaenoic Acid (DHA).
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Omega-6/Omega-3 Essential Fatty Acid Ratio and Chronic Diseases
TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries that are being exported to the rest of the world.
View on Taylor & Francis
Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain
  • A. Simopoulos
  • Biology, Medicine
    Molecular Neurobiology
  • 29 January 2011
TLDR
It is suggested that human beings evolved on a diet that had a ratio of omega-6 to omega-3 fatty acids (FA) of about 1/1; whereas today, Western diets have a ratios of 10/1 to 20–25/1, indicating that Western diets are deficient in omega- 3 FA.
View on Springer
Human requirement for N-3 polyunsaturated fatty acids.
TLDR
A balanced n-6/n-3 ratio in the diet is essential for normal growth and development and should lead to decreases in cardiovascular disease and other chronic diseases and improve mental health.
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