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A CRISPR-Cas9 Gene Drive System Targeting Female Reproduction in the Malaria Mosquito vector Anopheles gambiae
Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonucleaseExpand
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Temperature Entrainment of Drosophila's Circadian Clock Involves the Gene nocte and Signaling from Peripheral Sensory Tissues to the Brain
Circadian clocks are synchronized by the natural day/night and temperature cycles. Our previous work demonstrated that synchronization by temperature is a tissue autonomous process, similar toExpand
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A CRISPR-Cas 9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
1Department of Life Sciences, Imperial College London, London, UK. 2Dipartimento di Medicina Sperimentale Via Gambuli, Centro di Genomica Funzionale, University of Perugia, Perugia, Italy.Expand
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A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such asExpand
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A Mechanosensory Pathway to the Drosophila Circadian Clock
Coordinating the Clock In flies, the mechanosensory chordotonal organs help to coordinate the effects of temperature on circadian cycles. Simoni et al. (p. 525) provide a mechanism by whichExpand
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Cryptochrome Antagonizes Synchronization of Drosophila’s Circadian Clock to Temperature Cycles
BACKGROUND In nature, both daily light:dark cycles and temperature fluctuations are used by organisms to synchronize their endogenous time with the daily cycles of light and temperature. ProperExpand
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Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster
Selfish genes are DNA elements that increase their rate of genetic transmission at the expense of other genes in the genome and can therefore quickly spread within a population. It has been suggestedExpand
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A draft genome sequence of an invasive mosquito: an Italian Aedes albopictus
Abstract The draft genome sequence of Italian specimens of the Asian tiger mosquito Aedes (Stegomyia) albopictus (Diptera: Culicidae) was determined using a standard NGS (next generation sequencing)Expand
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The Pyrexia transient receptor potential channel mediates circadian clock synchronization to low temperature cycles in Drosophila melanogaster
Circadian clocks are endogenous approximately 24 h oscillators that temporally regulate many physiological and behavioural processes. In order to be beneficial for the organism, these clocks must beExpand
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Author Correction: A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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