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Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
The genome sequence of the protist Trichomonas vaginalis predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria. Expand
Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives.
Results show that nitroderivative therapy for T. cruzi infections is unsatisfactory and cannot be recommended since it fails to eradicate the parasite or change the progression of heart disease in chronic Chagas patients. Expand
Novel Core Promoter Elements and a Cognate Transcription Factor in the Divergent Unicellular Eukaryote Trichomonas vaginalis
Two elements that lack sequence similarity to the known protein-coding gene core promoter, motif 3 (M3) and motif 5 (M5), were identified and Mutational and functional analyses demonstrate that both are novel core promoter elements. Expand
The Interplay of Host Microbiota and Parasitic Protozoans at Mucosal Interfaces: Implications for the Outcomes of Infections and Diseases
This review focuses attention on the importance of considering polymicrobial associations, i.e., parasitic protozoans and the host microbiota, for understanding these human infections in their natural microbial context. Expand
Six-year follow-up survey of sexually transmitted diseases in Brasilia, the Capital of Brazil.
There was a high prevalence of bacterial vaginosis, trichomoniasis and candidiasis, with suggestive changes over the years, and a large proportion of cases involved late stages of cervical cancer, indicating the necessity of prompt attendance of the population in a routine gynecological prevention program. Expand
The adherence of Trichomonas vaginalis to host ectocervical cells is influenced by lactobacilli
Lactobacilli can modulate adhesion of T vaginalis by significantly modifying the natural adhesive properties of various T vaginal is strains in a dose-dependent manner. Expand
An improved quantitative method to assess adhesive properties of Trichomonas vaginalis to host vaginal ectocervical cells using flow cytometry.
Microbial adhesion is a critical step for infection and colonization of the host. Trichomonas vaginalis, a human urogenital extracellular parasite, relies on host cell adhesion for infection andExpand
Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure.
Structural models predict that T. vaginalis snRNAs contain conserved sequences and motifs similar to those found in other examined eukaryotes, and data indicate that mechanisms of intron recognition as well as coordination of the two catalytic steps of splicing have been conserved throughout eukARYotic evolution. Expand
Trichomonas vaginalis: intrastrain polymorphisms within the ribosomal intergenic spacer do not correlate with clinical presentation.
Analysis of restriction length polymorphism (RFLP) within the intergenic spacer of the ribosomal DNA (IGS) from 60 clinically defined isolates of T. vaginalis showed absence of correlation between the genetic relatedness of the isolates and symptomatology. Expand
A food-grade delivery system for Lactococcus lactis and evaluation of inducible gene expression
The level of expression of theheterologous protein after nisin induction was similar in the crossover mutants, suggesting that a single copy of the heterologous gene can be used to produce the protein of interest. Expand