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UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
TLDR
The UK Biobank is described, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.
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2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
TLDR
This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
TLDR
This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
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Body mass index as a predictor of fracture risk: A meta-analysis
TLDR
It is concluded that low BMI confers a risk of substantial importance for all fractures that is largely independent of age and sex, but dependent on BMD.
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Identification of late-onset hypogonadism in middle-aged and elderly men.
TLDR
Symptoms of poor morning erection, low sexual desire, erectile dysfunction, inability to perform vigorous activity, depression, and fatigue were significantly related to the testosterone level, and an inverse relationship between an increasing number of sexual symptoms and a decreasing testosterone level was observed.
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2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
TLDR
This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
View on PubMed
Epidemiology and genetics of rheumatoid arthritis
TLDR
There has recently been renewed interest in the link between cigarette smoking and RA, and the data presented so far are consistent with and suggestive of an increased risk.
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Statistical methods for assessing observer variability in clinical measures.
TLDR
This review attempts to summarise in simple terms the statistical techniques available to quantify the variation within and between observers.
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The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
TLDR
BMD and clinical risk factors predict hip and other osteoporotic fractures with higher specificity and sensitivity than either alone and provide the basis for the integrated use of validated Clinical risk factors in men and women to aid in fracture risk prediction.
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Predictive Value of BMD for Hip and Other Fractures
The relationship between BMD and fracture risk was estimated in a meta‐analysis of data from 12 cohort studies of ∼39,000 men and women. Low hip BMD was an important predictor of fracture risk. The…
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