• Publications
  • Influence
Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast
The cytoplasmic localization of messenger RNA creates an asymmetric distribution of proteins that specify cell fate during development in multicellular eukaryotes. The protein Ash1 is a cell-fateExpand
  • 391
  • 35
  • PDF
Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.
Transcription of many yeast genes requires the SWI/SNF regulatory complex. Prior studies show that reduced transcription of the HO gene in swi and snf mutants is partially relieved by mutations inExpand
  • 247
  • 18
Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator
  • V. Q. Nguyen, A. Sil
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 25 March 2008
Histoplasma capsulatum, a fungal pathogen of humans, switches from a filamentous spore-forming mold in the soil to a pathogenic budding-yeast form in the human host. This morphologic switch, which isExpand
  • 147
  • 11
  • PDF
Identification of an Asymmetrically Localized Determinant, Ash1p, Required for Lineage-Specific Transcription of the Yeast HO Gene
S. cerevisiae cells exhibit asymmetric determination of cell fate. Cell division yields a mother cell, which is competent to transcribe the HO gene and switch mating type, and a daughter cell, whichExpand
  • 279
  • 9
A Conserved Transcriptional Regulator Governs Fungal Morphology in Widely Diverged Species
Fungi exhibit a large variety of morphological forms. Here, we examine the functions of a deeply conserved regulator of morphology in three fungal species: Saccharomyces cerevisiae, Candida albicans,Expand
  • 61
  • 7
  • PDF
Histoplasma Requires SID1, a Member of an Iron-Regulated Siderophore Gene Cluster, for Host Colonization
The macrophage is the primary host cell for the fungal pathogen Histoplasma capsulatum during mammalian infections, yet little is known about fungal genes required for intracellular replication inExpand
  • 94
  • 6
Evolution of the Mating Type Locus: Insights Gained from the Dimorphic Primary Fungal Pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii
ABSTRACT Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specifyExpand
  • 84
  • 6
  • PDF
A Temperature-Responsive Network Links Cell Shape and Virulence Traits in a Primary Fungal Pathogen
Analysis of a transcriptional regulatory network in a fungal pathogen reveals that four interdependent transcription factors respond to human body temperature to trigger changes in cell shape andExpand
  • 83
  • 6
  • PDF
Identifying phase-specific genes in the fungal pathogen Histoplasma capsulatum using a genomic shotgun microarray.
A fundamental feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a mycelial phase in the soil to a yeast phase in its human host. Each form plays a critical role inExpand
  • 106
  • 5
  • PDF
N-acetylglucosamine (GlcNAc) Triggers a Rapid, Temperature-Responsive Morphogenetic Program in Thermally Dimorphic Fungi
The monosaccharide N-acetylglucosamine (GlcNAc) is a major component of microbial cell walls and is ubiquitous in the environment. GlcNAc stimulates developmental pathways in the fungal pathogenExpand
  • 48
  • 5
  • PDF