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Spectrin and calpain: a ‘target’ and a ‘sniper’ in the pathology of neuronal cells
Abstract.It is well documented that activation of calpain, a calcium-sensitive cysteine protease, marks the pathology of naturally and experimentally occuring neurodegenerative conditions.Expand
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Spectrins: a structural platform for stabilization and activation of membrane channels, receptors and transporters.
This review focuses on structure and functions of spectrin as a major component of the membrane skeleton. Recent advances on spectrin function as an interface for signal transduction mediation and aExpand
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Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.
The review is focused on the domain structure and function of protein 4.1, one of the proteins belonging to the membrane skeleton. The protein 4.1 of the red blood cells (4.1R) is a multifunctionalExpand
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The effect of statins on cancer cells—review
Statins [3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, abbreviated HMGCR) inhibitors], are well-known cholesterol-depleting agents. Since the early 1990s, it has been known thatExpand
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Attaching a spin to a protein -- site-directed spin labeling in structural biology.
Site-directed spin labeling and electron paramagnetic resonance spectroscopy have recently experienced an outburst of multiple applications in protein science. Numerous interesting strategies haveExpand
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Synapsin I-mediated interaction of brain spectrin with synaptic vesicles
We have established a new binding assay in which 125I-labeled synaptic vesicles are incubated with brain spectrin covalently immobilized on cellulosic membranes in a microfiltration apparatus. WeExpand
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Spectrin (βSpIIΣ1) is an essential component of synaptic transmission
Abstract The cellular mechanism that underlies the regulated release of synaptic vesicles during neurotransmission is not fully known. Our previous data has shown that brain spectrinExpand
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Brain spectrin (fodrin) interacts with phospholipids as revealed by intrinsic fluorescence quenching and monolayer experiments.
We demonstrate that phospholipid vesicles affect the intrinsic fluorescence of isolated brain spectrin. In the present studies we tested the effects of vesicles prepared from phosphatidylcholineExpand
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Protein palmitoylation: Palmitoyltransferases and their specificity
A plethora of novel information has emerged over the past decade regarding protein lipidation. The reversible attachment of palmitic acid to cysteine residues, termed S-palmitoylation, has focused aExpand
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Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.
The nonreceptor tyrosine kinases Abl and Arg are among the most well-characterized tyrosine kinases in the human genome. The activation of Abl by N-terminal fusions with Bcr (Bcr-Abl) or Gag (v-Abl)Expand
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