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Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
Recent evidence indicates that growing blood-vessel sprouts consist of endothelial cells with distinct cell fates and behaviours; however, it is not clear what signals determine these sprout cellExpand
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Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas
Zebrafish provide a highly versatile model in which to study vertebrate development. Many recent studies have elucidated early events in the organogenesis of the zebrafish pancreas; however, severalExpand
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Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling
During angiogenic sprouting, newly forming blood vessels need to connect to the existing vasculature in order to establish a functional circulatory loop. Previous studies have implicated geneticExpand
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Chemokine signaling guides regional patterning of the first embryonic artery.
The aorta traverses the body, yet little is known about how it is patterned in different anatomical locations. Here, we show that the aorta develops from genetically distinct endothelial cellsExpand
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Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
Endothelial tip cells guide angiogenic sprouts by exploring the local environment for guidance cues such as vascular endothelial growth factor (VegfA). Here we present Flt1 (Vegf receptor 1) loss-Expand
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Distinct Notch signaling outputs pattern the developing arterial system
Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated theExpand
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Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish
Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate aExpand
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Modulation of VEGF signalling output by the Notch pathway
The formation of blood vessels within the vascular system entails a variety of cellular processes, including proliferation, migration and differentiation. In many cases, these diverse processes needExpand
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Reiterative use of the notch signal during zebrafish intrahepatic biliary development
The Notch signaling pathway regulates specification of zebrafish liver progenitor cells towards a biliary cell fate. Here, using staged administration of a pharmacological inhibitor of Notch receptorExpand
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A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.
In this work we describe a forward genetic approach to identify mutations that affect blood vessel development in the zebrafish. By applying a haploid screening strategy in a transgenic backgroundExpand
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