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The effects of the cyclosporin A, a P‐glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study
- T. Tsai, S. C. Liu, P. Tsai, L. Ho, A. Shum, C. Chen
- Chemistry, Medicine
- British journal of pharmacology
- 1 December 2002
Baicalein is a bioactive flavonoid isolated from the root of Scutellaria baicalensis Georgi, a medicinal herb that has been used since ancient times to treat bacterial infections. As little is known… Expand
Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus.
- G. Wang, A. Shum, +4 authors C. Chen
- Medicine, Chemistry
- The Journal of pharmacology and experimental…
- 1 April 2001
In vivo and in vitro studies were carried out to examine the putative hypotensive actions of S-petasin, a sesquiterpene extracted from the medicinal plant Petasites formosanus. Intravenous S-petasin… Expand
Ethanol modulates induction of nitric oxide synthase in glial cells by endotoxin.
Although ethanol has long been recognized as an immunosuppressant, the effects of ethanol on immune functions in the central nervous system (CNS) have not been well characterized. Glial cells… Expand
Pharmacokinetics of glycyrrhizin after intravenous administration to rats.
A simple high-performance liquid chromatographic method was developed to study the pharmacokinetics of glycyrrhizin in the rat after bolus intravenous administration at a dose of 20, 50, or 100… Expand
Influence of ambient temperature on excretion of catecholamines and metabolites.
Abstract : The study demonstrates the influence of ambient temperature on the excretion of epinephrine, norepinephrine, and their major metabolites. As a result of this work it is concluded that… Expand
Oxidative neurotoxicity in rat cerebral cortex neurons: Synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen‐activated protein kinase and caspase‐3
Oxidative stress in the brain has been increasingly associated with the development of numerous human neurological diseases. Microglia, activated upon neuronal injury or inflammatory stimulation, are… Expand
Production of macrophage inflammatory protein‐2 following hypoxia/reoxygenation in glial cells
Polymorphonuclear neutrophils (PMNs) are known to mediate brain inflammation following hypoxia/reoxygenation (H/R), but the precise mechanisms leading to PMN recruitment are undefined. The… Expand
Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons: Prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median…
The role of PRL in mediating the haloperidol-induced increase in tuberoinfundibular dopamine synthesis rate was assessed by studying the effects of administration of PRL antiserum. Antiserum to PRL… Expand
Serotonin Metabolism in the Normal and Failing Hamster Heart
Serotonin has been found in the heart. Because cardiac serotonin is a potential endogenous source of inotropic support, an understanding of its metabolism in normal and failing hearts may be… Expand
Inhibition of aldosterone production by testosterone in male rats.
- M. Kau, M. Lo, +9 authors P. Wang
- Biology, Medicine
- Metabolism: clinical and experimental
- 1 September 1999
In vivo and in vitro experiments were designed to assess the effect of testosterone on aldosterone secretion in male rats. Orchidectomized rats were injected subcutaneously with oil or testosterone… Expand