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Long-term persistence of hormonal adaptations to weight loss.
BACKGROUND After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur. Whether these changes are transient orExpand
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Ketosis and appetite-mediating nutrients and hormones after weight loss
Background/Objectives:Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage weight regain. There is some evidence that ketogenic diets suppressExpand
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Gastrin-releasing peptide and cancer.
Over the past 20 years, abundant evidence has been collected to suggest that gastrin-releasing peptide (GRP) and its receptors play an important role in the development of a variety of cancers. InExpand
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Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome
Objective The purpose of this study was the clinical and pathological characterisation of a new autosomal dominant gastric polyposis syndrome, gastric adenocarcinoma and proximal polyposis of theExpand
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Expression, processing, and secretion of gastrin in patients with colorectal carcinoma.
BACKGROUND & AIMS The relationship between gastrin and the development of colorectal carcinoma (CRC) remains controversial. Problems with previous studies include failure to measure all forms ofExpand
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Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.
BACKGROUND AND AIMS We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes inExpand
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BRIEF REVIEW BIOLOGY OF GUT CHOLECYSTOKININ AND GASTRIN RECEPTORS
1. The stomach hormone gastrin and the intestinal hormone cholecystokinin (CCK) share a common C‐terminal pentapep‐tide sequence but have different biological roles. Gastrin is the major stimulant ofExpand
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Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.
Hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated andExpand
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Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations.
BACKGROUND Weight regain after weight loss may not be due primarily to voluntary return to social habits but may be explained by changes in peripheral hormonal signals activating hunger andExpand
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Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion
The pancreatic secretagogue cholecystokinin (CCK) is widely thought to stimulate enzyme secretion by acinar cells indirectly via activation of the vagus nerve. We postulate an alternative pathway forExpand
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