Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. Speliotes, C. Willer, R. Loos
- Biology, Medicine
- 2010
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, Ellen M. Schmidt, G. Abecasis
- BiologyNature Genetics
- 6 October 2013
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, I. Barroso
- Medicine, BiologyNature Genetics
- 17 January 2010
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
- C. Willer, S. Sanna, G. Abecasis
- BiologyNature Genetics
- 1 February 2008
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising…
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, M. McCarthy
- BiologyNature Genetics
- 26 July 2012
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, T. Frayling
- BiologyNature Genetics
- 8 September 2014
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Hundreds of variants clustered in genomic loci and biological pathways affect human height
- H. Lango Allen, K. Estrada, J. Hirschhorn
- BiologyNature
- 10 August 2010
It is shown that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, and indicates that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
- Rongze Yang, Mi-Jeong Lee, D. Gong
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 June 2006
Central (visceral) obesity is more closely associated with insulin resistance, type 2 diabetes, and cardiovascular disease than is peripheral [subcutaneous (sc)] obesity, but the underlying mechanism…
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
- S. A. Scott, K. Sangkuhl, A. Shuldiner
- BiologyClinical pharmacology and therapy
- 1 September 2013
Cytochrome P450 (CYP)2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 loss‐of‐function alleles impair formation of active metabolites, resulting in reduced…
...
...