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Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines.
TLDR
It is concluded that unlike regular insulin and other insulin analogs, Lantus strongly activates the IGF-IR and the MAP kinase pathway in MCF7 cells and is a strong mitogen for cells characterized by a high-IGF-IR/IR ratio.
Proliferative effects of insulin analogues on mammary epithelial cells.
TLDR
Only insulin glargine showed a significantly higher proliferative effect on MCF-7 breast cancer cells compared to regular insulin among a panel of short- or long-acting insulin analogues, that are in clinical use.
Proliferative effect of Apidra® (insulin glulisine), a rapid-acting insulin analogue on mammary epithelial cells
TLDR
It is shown that Apidra and Actrapid (recombinant human insulin) have similar proliferative effects on benign MCF10A and tumorigenic MCF7 cells and on epithelial cells of mouse mammary gland.
Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor.
TLDR
It is demonstrated that GSK-3 is required for E2-induced ERalpha phosphorylation at Ser-118 and full transcriptional activity of the receptor upon E2 stimulation and plays a crucial role in ERalpha protein stabilization and turnover.
Avoiding permanent atrial fibrillation: treatment approaches to prevent disease progression
TLDR
Evaluating the clinical correlates of arrhythmia progression and risk stratification techniques available to assess probability of AF progression finds that there may be no mortality benefit to using a rhythm control approach in comparison with rate control of AF.
Risk of Colorectal Adenomas in Women with Prior Breast Cancer
TLDR
Comparing the prevalence of colorectal adenomas and any CRC in breast cancer survivors with those who have no history of prior cancer and assess any difference with use of antiestrogen therapy revealed that adjuvant antiestrogens therapy was not significantly associated with an increased risk of advanced adenoma.
INSULIN ANALOGUES: ANALYSIS OF PROLIFERATIVE POTENCY AND CHARACTERIZATION OF RECEPTORS AND SIGNALLING PATHWAYS ACTIVATED IN HUMAN MAMMARY EPITHELIAL CELLS
TLDR
This thesis aimed to study and compare in detail the proliferative potency of insulin analogues available for therapeutical use in insulin responsive mammary epithelial cell lines and to clarify the molecular and biochemical mechanism behind the proliferationative potency.
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