A. Shirai

Publications39
h-index11
Citations374
Highly Influential Citations10
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Prognostic value of cell motility activation factors in patients with tongue squamous cell carcinoma.
Cell motility plays a crucial role in invasion and metastasis of malignant tumors. Both AMFR and c-Met, known as key factors in up-regulation of cell motility, are overexpressed in a variety of… Expand
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A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer.
OBJECTIVE Matrix metalloproteinase-1 (MMP-1) and interleukin-8 (IL-8) play an important role in cancer development and metastasis. There is a single nucleotide polymorphism (SNP) located in the… Expand
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Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
P-glycoprotein, a multidrug transporter protein, exists in the brain capillary endothelium. To study the function of P-glycoprotein in brain capillary endothelium as a barrier against cyclosporin A,… Expand
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Hair follicle elongation in organ culture of skin from newborn and adult mice.
By means of skin organ culture, some biological characteristics of hair follicle elongation were examined. When skin sections from 6-day-old C3H mice were cultured, spontaneous elongation of hair… Expand
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Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth
We have previously reported that procyanidin oligomers selectively promote growth of murine hair epithelial cells in vitro and stimulate anagen induction in vivo. We report here the possible… Expand
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KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.
KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of… Expand
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IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice.
The phenotype and antigenic specificity of cells secreting interleukin (IL) 4, IL-6, and interferon gamma was studied in mice during primary and secondary immune responses. T lymphocytes were the… Expand
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Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type‐1
CD40 ligand is a costimulatory molecule which acts a potent immunomodulator. We found the mice inoculated with human CD40 ligand expression plasmid (pMEhCD40L) combined with human immunodeficiency… Expand
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Expression of intercellular adhesion molecule (ICAM)‐1 in adenoid cystic carcinoma of the head and neck
Objectives/Hypothesis: Adenoid cystic carcinoma of the head and neck (ACCHN) is characterized by late recurrence and frequent distant metastasis. Tumor attack by cytotoxic T lymphocytes and… Expand
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Inhibition of different steps of the ubiquitin system by cisplatin and aclarubicin.
Ubiquitin is involved in such fundamental cellular processes as cell cycle control, DNA repair, protein degradation and stress responses. We previously reported that cisplatin could inhibit the… Expand
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