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Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil
Japanese patients with chronic rhinosinusitis with nasal polyps (CRSwNP), differing from European and U.S. patients, are suggested to show two distinct phenotypes: Th2‐polarized and Th1‐shiftedExpand
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  • Open Access
Peroxide Tone in Human Inferior Nasal Turbinate with Allergy
Background: The nose is chronically exposed to oxidative stress, which can easily lead to reactive oxygen species (ROS)-mediated damage and lipid oxidative damage of the upper airway. ROS may alsoExpand
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Fungal extracts detected in eosinophilic chronic rhinosinusitis induced cytokines from the nasal polyp cells
The role of fungi in chronic rhinosinusitis (CRS) is still controversial. The present study was conducted to detect and identify fungal species from the nasal polyp tissues of eosinophilic andExpand
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  • Open Access
Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps
Background: Eosinophils generate large amounts of oxidant species. The eosinophil-dominant type of chronic rhinosinusitis (CRS) with nasal polyps is related to more extensive disease and a decreasedExpand
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Comparative analysis of cytokine release from epithelial cell cultures of the upper airway.
INTRODUCTION Upper airway epithelial cells show a multi-potential ability to produce a variety of cytokines/chemokines in the steady-state and under external stimuli. OBJECTIVE To compare variousExpand
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Postoperative Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: Impact of High-Dose Corticosteroid Nasal Spray
Introduction  Eosinophilic chronic rhinosinusitis (ECRS) is characterized by an eosinophilic inflammation driven by Th2-type cytokines. Glucocorticosteroids are the most common first-line treatmentExpand
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  • Open Access
Changes in Contents ofArachidonic Acid Metabolites inNasal Lavage and Mucosal Tissuesin response to Allergen Challengein Patients with Allergic Rhinitis
Background: Allergic rhinitis is recognized as being not purely a histamine-related disease. Three arachidonate metabolites, i.e. leukotriene (LT), thromboxane (TX) A2 and prostaglandin (PG) D2, haveExpand
Orbital Injury in Endoscopic Sinus Surgery for Sinonasal Inflammatory Disorders: Juntendo’s Ten-Year Experience
Orbital injury and complications are commonly encountered in endoscopic sinus surgery (ESS) despite advances in techniques and instrumentation. For the recent 10 years, we summarized the experienceExpand
Complications of Short-Course Oral Corticosteroids for Eosinophilic Chronic Rhinosinusitis during Long-Term Follow-Up
The literature strongly recommends the use of oral corticosteroids in the management of patients with eosinophilic chronic rhinosinusitis (CRS) with nasal polyps. Although potential complicationsExpand