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Hypolipidemic effect of mannans from C. albicans serotypes a and B in acute hyperlipidemia in mice.
Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application
- T. A. Korolenko, N. Bgatova, M. Ovsyukova, A. Shintyapina, V. Vetvicka
- Biology, MedicineMolecules
- 1 April 2020
This review will present up-to-date information regarding experimental hypolipidemic polysaccharide compounds that hold promise for medicine regarding β-glucans and Phagocyte-specific chitotriosidase in humans.
Filaggrin mutations in a Western siberian population and their association with atopic dermatitis in children.
- E. G. Komova, A. Shintyapina, V. Vavilin
- BiologyGenetic testing and molecular biomarkers
- 3 December 2014
A case-control study showed that the deletion 2282del4 was associated with atopic dermatitis in children (odds ratio 7.01; p<0.001) and the other mutations were not.
A comparative study of the hypolipidaemic effects of a new polysaccharide, mannan Candida albicans serotype A, and atorvastatin in mice with poloxamer 407‐induced hyperlipidaemia
- T. Korolenko, T. Johnston, L. V. Sakhno
- BiologyThe Journal of pharmacy and pharmacology
- 5 October 2016
We evaluated the hypolipidaemic effect of mannan Candida albicans serotype A, relative to atorvastatin, in a mouse model of hyperlipidaemia.
The gene expression profile of a drug metabolism system and signal transduction pathways in the liver of mice treated with tert-butylhydroquinone or…
Change in gene expression of phase I, II, and III drug metabolizing enzymes/transporters as well as protein levels and activities of cytochromes P450 (CYPs) elicited by tBHQ and its structural homolog TS-13 in the mouse liver are studied.
Effects of Simvaglyzin and Atorvaglyzin on the Expression of 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase in Rat Liver
- E. Stakhneva, V. Vavilin, Y. Ragino, O. Safronova, A. Shintyapina, M. V. Ivanova
- Biology, ChemistryBulletin of Experimental Biology and Medicine
- 24 November 2013
Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with…
Early Parkinson’s Disease-Like Pathology in a Transgenic Mouse Model Involves a Decreased Cst3 mRNA Expression But Not Neuroinflammatory Response in the Brain
The modulation of mRNA levels of Cst3 and autophagy marker Becn1 in the brain by ceftriaxone treatment supports the potential of autophagic modulation through Cystatin C at early stages of PD-like pathology.
Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression
The major roles of mushroom-derived β-glucans on cancer progression are highlighted and the importance of knowing the carrier and removal status of these polymers in the environment is highlighted.
Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells
- A. Shintyapina, E. Shults, A. Pokrovsky
- ChemistryRussian Journal of Bioorganic Chemistry
- 1 November 2007
The amides of betulonic acid proved to be the most effective inducers of apoptosis in tumor cells by betulin derivatives at a concentration of 10 μg/ml.
The regulatory role of cystatin C in autophagy and neurodegeneration
- T. A. Korolenko, A. Shintyapina, T. Amstislavskaya
- BiologyVavilov Journal of Genetics and Breeding
- 7 July 2019
Using a transgenic mouse model of Parkinson’s disease (5 months old), a significant increase in osmotic susceptibility of brain lysosomes, depending on autophagy is demonstrated, an indication of an important function of this cysteine protease inhibitor in the brain.