• Publications
  • Influence
Intoxication With Endogenous Angiotensin II: A COVID-19 Hypothesis
TLDR
It is hypothesize that, like in avian influenza, the outlook of COVID-19 is negatively correlated with the intracellular accumulation of angiotensin II promoted by the viral blockade of its degrading enzyme receptors.
Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis
TLDR
A search of predicted microRNA targets, utilizing the public domain tool miRDB, found that microRNA-6842-3p modulates the SLC6A1 and CHRNA7 genes both of which were previously hypothesized to inhibit the thirst sensation by their action on SFO.
Neurodegeneration Behind Bars: from Molecules to Jurisprudence
TLDR
A multidisciplinary approach to bvFTD is emphasized; it is believed that input from disciplines such as neurobiology, psychology, psychiatry, forensic psychiatry, and jurisprudence could help to comprehend better this complex disorder.
The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling
TLDR
It is surmised that novel Alzheimer's disease findings, including neuronal somatic mosaicism, iron dyshomeostasis, aggressive glial phenotypes, and loss of aerobic glycolysis, can be explained by the infection-senescence model.
The Obesity–Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients
TLDR
A look beyond psychopharmacological interventions and discusses dietary and physical therapy approaches for addressing obesity and metabolic dysfunction in a preventive manner to reduce the excessive impulsivity, decreasing the risk for aggression.
Non-Neuronal Acetylcholine: The Missing Link Between Sepsis, Cancer, and Delirium?
TLDR
It is hypothesized that age-induced ACh deficiency is the result of an epigenomic dysfunction of microRNA-6775 (miR- 6775), which silences the transcription of CHRNA7 gene [coding for alpha 7 nicotinic cholinergic receptors (nAChRs], which may predispose elderly individuals to inflammation, neuroinflammation, and delirium.
COVID-19, ferrosenescence and neurodegeneration, a mini-review
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