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Interactions and regulation of molecular motors in Xenopus melanophores
TLDR
The Xenopus melanophore model system, where three motors, kinesin II, cytoplasmic dynein, and myosin V, drive aggregation or dispersion of pigment organelles called melanosomes, shows that there is a continual tug-of-war between the actin and microtubule transport systems. Expand
Dynactin is required for bidirectional organelle transport
TLDR
Dynactin is required for transport activity of microtubule motors of opposite polarity, cytoplasmic dynein and kinesin II, and may provide a new mechanism to coordinate their activities, as revealed in Xenopus laevis melanophores. Expand
Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors.
TLDR
The velocity distribution of melanosomes transported by cytoplasmic dynein or kinesin-2 under conditions of aggregation and dispersion presented several peaks and could not be fit with a single Gaussian function, so it is postulated that the melanosome velocity depends linearly on the number of active motors. Expand
Synapse formation by hippocampal neurons from agrin-deficient mice.
TLDR
Results indicate that the z+ forms of agrin are dispensable for glutamatergic and GABAergic synaptic differentiation in the central nervous system. Expand
Clustering of Gephyrin at GABAergic but Not Glutamatergic Synapses in Cultured Rat Hippocampal Neurons
TLDR
It is suggested that gephyrin may function to anchor GABA and glycine receptors, but not glutamate receptors, at postsynaptic sites on central neurons, and the possibility that g Nephyrin has additional functions, independent of its role at synapses is raised. Expand
Regulation of Bidirectional Melanosome Transport by Organelle Bound MAP Kinase
TLDR
This work directly demonstrates that melanosome transport is regulated by ERK signaling, and proposes that signaling of organelle bound ERK is a key pathway that regulates bidirectional, microtubule-based melanosomes transport. Expand
Tracking melanosomes inside a cell to study molecular motors and their interaction
TLDR
A technique for tracking individual motors of each type, both individually and in their interaction, with high spatial and temporal localization accuracy is described, which enabled us to observe smoother melanosome transport (with fewer pauses), in the absence of intermediate filaments (IFs). Expand
The dynamic properties of intermediate filaments during organelle transport
TLDR
It is shown that melanophores possess a complex network of vimentin IFs which interact with melanosomes, and a role for IFs as modulators of granule movement is suggested. Expand
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action
TLDR
Dynapyrazoles are identified as inhibitors more potent than ciliobrevins of cytoplasmic dyneins, suggesting that chemical-structure-based analyses can lead to inhibitors with improved properties and distinct modes of inhibition. Expand
Differential regulation of dynein-driven melanosome movement.
TLDR
The data indicate that melanosome-associated dynein is regulated independently of bulk cytoplasmic dyne in and involves a subfraction of Dynein with a distinct subunit composition. Expand
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