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Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide
The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.
Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression
This study investigated brain regions that are known to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations and suggests a global brain alteration of GLU and GABA receptor subunit genes in these conditions.
Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
Gene misexpression in BA46 was most pronounced between the two suicide groups, with many significant genes involved in GABAergic neurotransmission, providing further support for a central glial pathology in depression and suicidal behavior.
Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.
- A. Desautels, G. Turecki, J. Montplaisir, A. Sequeira, A. Verner, G. Rouleau
- BiologyAmerican journal of human genetics
- 1 December 2001
These findings represent the first mapping of a locus conferring susceptibility to RLS, and positioning the RLS-predisposing gene in a 14.71-cM region between D 12S1044 and D12S78 is refined.
Implication of SSAT by gene expression and genetic variation in suicide and major depression.
A role for SSAT, the rate-limiting enzyme in the catabolism of polyamines, in suicide and depression and a role for the SSAT342 locus in the regulation of SSAT gene expression are suggested.
Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers.
A reduction of TrkB.T1 expression in the frontal cortex of a subpopulation of suicide completers is associated with the methylation state of the promoter region, and this downregulation is mediated by an epigenetic process.
A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome
- Taraneh Esmailpour, Hamidreza Riazifar, Taosheng Huang
- Medicine, BiologyJournal of Medical Genetics
- 15 January 2014
A mutation in the intron 7 splice donor site of the N-acetyltransferase NAA10 gene is identified that is the cause of Lenz microphthalmia syndrome in this family, likely through the dysregulation of the retinoic acid signalling pathway.
Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex.
Fatty acid composition in postmortem brains of people who completed suicide.
- A. Lalovic, E. Levy, L. Canetti, A. Sequeira, A. Montoudis, G. Turecki
- Psychology, MedicineJournal of psychiatry & neuroscience : JPN
- 1 September 2007
Further research is required to better understand the link between fatty acids in the peripheral circulation and those in the central nervous system before determining whether fatty acids play a mediating role in suicidal behaviour.
Patterns of gene expression in the limbic system of suicides with and without major depression
The data suggest that specific patterns of expression in the limbic system contribute to the etiology of depression and suicidal behaviors and highlight the role of the hippocampus in major depression.