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Rest in Drosophila Is a Sleep-like State
JETLAG Resets the Drosophila Circadian Clock by Promoting Light-Induced Degradation of TIMELESS
TLDR
The results suggest that JET is essential for resetting the clock by transmitting light signals from CRY to TIM, thereby reconstituting the acute response + of the circadian clock to light in a cell culture system.
Sleep in Drosophila is regulated by adult mushroom bodies
TLDR
It is shown that large changes in sleep are achieved by spatial and temporal enhancement of cyclic-AMP-dependent protein kinase activity specifically in the adult mushroom bodies of Drosophila, which links sleep regulation to an anatomical locus known to be involved in learning and memory.
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.
TLDR
A clock mutation, timeless (tim), is described that produces arrhythmia for bothClosion and locomotor activity of adults occur rhythmically in Drosophila melanogaster with a circadian period of about 24 hours.
Isolation of timeless by PER Protein Interaction: Defective Interaction Between timeless Protein and Long-Period Mutant PERL
TLDR
The cloning of complementary DNAs derived from the tim gene in a two-hybrid screen for PER-interacting proteins and the demonstration of a physical interaction between the tim protein (TIM) and PER in vitro are reported.
A Drosophila model for age-associated changes in sleep:wake cycles
TLDR
Drosophila is established as a valuable model for studying age-associated sleep fragmentation and breakdown of rhythm strength, and changes in sleep:wake cycles are indicated to be an integral part of the physiological aging process.
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