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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update
Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in many processes, including DNA repair and cell death. The best known poly(ADP-ribosylating) enzime,Expand
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Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.
Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-dependent kinase inhibitor p21(CDKN1A) plays essential roles in the DNA damage response, by inducing cellExpand
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Functional analysis and case-control study of -160C/A polymorphism in the E-cadherin gene promoter: association with cancer risk.
BACKGROUND A C-->A polymorphism within the CDH1 (E-cadherin) promoter seems to be associated with a reduced efficiency of gene transcription in vitro. Due to the crucial role of E-cadherin inExpand
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Berberine: new perspectives for old remedies.
Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. Among them, the natural isoquinoline alkaloid berberine has been employed inExpand
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Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis
We demonstrate here that the release of mature cytochrome c from mitochondria is a cellular response to the depletion of glutathione, the main intracellular antioxidant, independently from theExpand
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CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
The proliferating cell nuclear antigen (PCNA) protein serves as a molecular platform recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) transactions.Expand
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PARP inhibitors: new tools to protect from inflammation.
Poly(ADP-ribosylation) consists in the conversion of β-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correctExpand
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Human Proliferating Cell Nuclear Antigen, Poly(ADP-ribose) Polymerase-1, and p21waf1/cip1
We addressed the analysis of the physical and functional association of proliferating cell nuclear antigen (PCNA), a protein involved in many DNA transactions, with poly(ADP-ribose) polymeraseExpand
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Rearrangement of nuclear ribonucleoprotein (RNP)‐containing structures during apoptosis and transcriptional arrest
Abstract The aim of this paper is to review the data in the literature concerning ribonucleoprotein components during apoptosis, where a major rearrangement of RNPs takes place. In parallel withExpand
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