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Multiple-laboratory comparison of microarray platforms
TLDR
A consortium of ten laboratories from the Washington, DC–Baltimore, USA, area was formed to compare data obtained from three widely used platforms using identical RNA samples to demonstrate that there are relatively large differences in data obtained in labs using the same platform, but that the results from the best-performing labs agree rather well.
Draft Genome of the Filarial Nematode Parasite Brugia malayi
TLDR
Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units.
Cholesterol 25‐hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
TLDR
The results suggest that the rapid induction of Ch25h and subsequent oxysterol synthesis may represent a component of the regulatory network that modulates the magnitude of innate immune reactions and possibly the nature and intensity of subsequent adaptive responses.
Homologues of Human Macrophage Migration Inhibitory Factor from a Parasitic Nematode
TLDR
Functional and structural data on cytokine-like proteins from a eukaryotic pathogen and remarkable conservation between a human cytokine and its parasite counterpart are reported, implying that MIF-mediated pathways play an important role in nematode immune evasion strategies.
Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria
TLDR
Findings confirm and extend findings regarding aspects of the earliest responses to malaria infection at the molecular level, which may be informative in elucidating how innate and adaptive immune responses may be modulated in different stages of infection.
The Wuchereria bancrofti orthologue of Brugia malayi SXP1 and the diagnosis of bancroftian filariasis.
Thioredoxin peroxidases from Brugia malayi.
Nematode sperm.
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