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Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma.
Serum hK6 concentration seems to be a new biomarker for ovarian carcinoma and may have value for disease diagnosis and prognosis and is a powerful predictor of disease-free and overall survival in both univariate and multivariate analyses.
Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negativeatients
MMP-9 status was compared with the concentration of cytosolic Cathepsin-D and with other established prognostic factors, in terms of disease free survival and overall survival and it is suggested that M MP-9 may be an independent favourable prognostic factor in node-negative breast cancer patients.
A new tumor suppressor role for the Notch pathway in bladder cancer
It is shown that Notch activation in bladder cancer cells suppresses proliferation both in vitro and in vivo by directly upregulating dual-specificity phosphatases (DUSPs), thus reducing the phosphorylation of ERK1 and ERK2 (ERK1/2).
Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.
Comparative analysis of genes located in this area, provides strong evidence that the human kallikrein gene family locus on chromosome 19 is considerably larger than previously thought, containing at least fifteen genes.
The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma.
Parallel overexpression of seven kallikrein genes in ovarian cancer.
The expression of five KLKs showed a strong degree of correlation at the protein level, suggesting the existence of a common mechanism or pathway that controls the expression of this group of adjacent genes during ovarian cancer progression.
Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma
The results indicate that LDHA up-regulation can be a predictor of poor prognosis in clear cell renal cell carcinoma, and represents a potential prognostic biomarker that can boost the accuracy of other prognostic models in patients with clear cell kidneys carcinoma.
BCL2 Family of Apoptosis-Related Genes: Functions and Clinical Implications in Cancer
Current knowledge of the function and molecular characteristics of a series of classic but also newly discovered genes of the BCL2 family are described, providing the basis for earlier and more accurate cancer diagnosis, prognosis and therapeutic intervention that targets the apoptosis pathways.
The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately
BACKGROUND Prostate-specific antigen (PSA) is the most reliable tumor marker available and is widely used for the diagnosis and management of prostate cancer. Unfortunately, PSA cannot distinguish