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Pharmacokinetics and metabolism of the anti-inflammatory agent Voltaren.
Diclofenac sodium, the active substance of Voltaren®, is totally absorbed following both oral and rectal administration and is excreted, mainly in metabolised form, partly in the urine and partly inExpand
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Perioperative medical management of patients with COPD
Chronic obstructive pulmonary disease (COPD) and heart diseases are considered independent risk factors for mortality and major cardiopulmonary complications after surgery. Coronary artery disease,Expand
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Stereological changes in the capillary network and nerve cells of the aging human brain
Stereologic parameters of the capillaries and nerve cells of the brain cortex and putamen were investigated. Thirty-eight brains from subjects aged between 19 and 94 years were examined. All casesExpand
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A new metabolite of diclofenac sodium in human plasma.
1. Among the phenolic metabolites of diclofenac in human plasma, an unknown compound (metabolite VI) was detected by h.p.l.c. and g.c. methods. This was also found in baboon plasma. 2. Metabolite VIExpand
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Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels
Interleukin-1 (IL-1) has been shown to induce inflammatory reactions in part through increased prostaglandin production. Prostaglandins of the E- and I-type sensitize nociceptors in peripheralExpand
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A sulphonamido-indanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats.
CGP 28237 (5-methylsulphonylamino-6-phenoxy-1-indanone) belongs to a series of structurally novel indanones. The compound is a weak acid (pK = 6.98), but it does not contain a carboxylic group. CGPExpand
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Postmortem changes in stereological parameters of cerebral capillaries.
The present study investigated the influence of different postmortem times on stereological parameters of capillaries in the cerebral cortex. For the human investigation different brain regions ofExpand
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Pharmacological properties of five diclofenac metabolites identified in human plasma
Five metabolites of diclofenac sodium (Voltarol®) have been identified in human plasma. All five metabolites were more than 50 times less potent than diclofenac in inhibiting PGE2 production inExpand
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