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Accurate Detection of Outliers and Subpopulations With Pmetrics, a Nonparametric and Parametric Pharmacometric Modeling and Simulation Package for R
Nonparametric population modeling algorithms have a theoretical superiority over parametric methods to detect pharmacokinetic and pharmacodynamic subgroups and outliers within a study population. Expand
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SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies.
We describe one such software tool, Simulation, Analysis, and Modeling Software II (SAAM II). Expand
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A program package for simulation and parameter estimation in pharmacokinetic systems.
A set of programs is presented which has been developed for parameter estimation and simulation of models arising from pharmacokinetic applications. Expand
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Model-Based, Goal-Oriented, Individualised Drug Therapy
SummaryThis article examines the use of population pharmacokinetic models to store experiences about drugs in patients and to apply that experience to the care of new patients. Population models areExpand
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Parametric and Nonparametric Population Methods
Background and objectivesThis study examined parametric and nonparametric population modelling methods in three different analyses. The first analysis was of a real, although small, clinical datasetExpand
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Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing
ABSTRACT We hypothesized that dosing vancomycin to achieve trough concentrations of >15 mg/liter overdoses many adults compared to area under the concentration-time curve (AUC)-guided dosing. WeExpand
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Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods.
As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and thenExpand
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Achieving Target Voriconazole Concentrations More Accurately in Children and Adolescents
ABSTRACT Despite the documented benefit of voriconazole therapeutic drug monitoring, nonlinear pharmacokinetics make the timing of steady-state trough sampling and appropriate dose adjustmentsExpand
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Individualizing Drug Dosage Regimens: Roles of Population Pharmacokinetic and Dynamic Models, Bayesian Fitting, and Adaptive Control
The role of population pharmacokinetic modeling is to store experience with drug behavior. The behavior of the model is then correlated with the clinical behavior of the patients studied, permittingExpand
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