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Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species.
TLDR
A size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress.
Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique.
TLDR
It is demonstrated that many metal and metal oxide nanomaterials agglomerate in solution and that depending upon the solution particleagglomeration is either agitated or mitigated.
Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells.
TLDR
The data revealed that already at a concentration of 10 microg/ml, silver nanoparticles specifically interact with Fyn kinase downstream of Ret and impair SSC proliferation in vitro, and it was demonstrated that the particle coating was degraded upon interaction with the intracellular microenvironment, reducing biocompatibility.
Are diamond nanoparticles cytotoxic?
TLDR
Assays of cell viability such as mitochondrial function (MTT) and luminescent ATP production showed that nanodiamonds were not toxic to a variety of cell types, and results suggest that nandiamonds could be ideal for many biological applications in a diverse range ofcell types.
Surface charge of gold nanoparticles mediates mechanism of toxicity.
TLDR
Results indicate that surface charge is a major determinant of how Au NPs impact cellular processes, with the charged NPs inducing cell death through apoptosis and neutral NPs leading to necrosis.
The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion.
TLDR
Results clearly demonstrate that nanoscale manganese can deplete DA, DOPAC, and HVA in a dose-dependent manner and further study is required to evaluate the specific intracellular distribution of Mn-40 nm nanoparticles, metal dissolution rates in cells and cellular matrices, and the propensity of Mn nanoparticles to cross the blood-brain barrier or be selectively uptaken by nasal epithelium.
Metal-based nanoparticles and their toxicity assessment.
TLDR
There are many challenges to overcome before the authors can determine if the benefits outweigh the risks associated with NPs, and some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form.
Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells.
TLDR
It is suggested that Ag-NPs may interact with the cerebral microvasculature producing a proinflammatory cascade, if left unchecked; these events may further induce brain inflammation and neurotoxicity.
Can silver nanoparticles be useful as potential biological labels?
TLDR
The induction of reactive oxygen species (ROS), degradation of mitochondrial membrane integrity, disruption of the actin cytoskeleton, and reduction in proliferation after stimulation with nerve growth factor were found after incubation with Ag nanoparticles at concentrations of 25 µg ml(-1) or greater, with a more pronounced effect produced by the hydrocarbon-based Ag nanoparticle in most cases.
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