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Ruthenium-Catalyzed Alder Ene Type Reactions. A Formal Synthesis of Alternaric Acid.
Alternaric acid, a nanomolar fungal germination inhibitor, is typified by a 1,4-diene, consisting of a terminal methylene and an (E)-1,2-disubstituted alkene. A new strategy for the synthesis of
Identical antagonist selectivity of central and peripheral alpha 1-adrenoceptors.
TLDR
Testing the relationship between binding affinity for alpha 1 -adrenoceptors and functional antagonism of drug-induced effects mediated by this type of alpha 1-receptor sites for alpha -sympatholytic drugs demonstrates that the binding affinity in vitro of antagonists foralpha 1-adrenOceptors corresponds with their functional antagonisms in vivo and in vitro.
Ruthenium-Catalyzed Alder Ene Type Reactions. A Formal Synthesis of Alternaric Acid
Alternaric acid, a nanomolar fungal germination inhibitor, is typified by a 1,4-diene, consisting of a terminal methylene and an (E)-1,2-disubstituted alkene. A new strategy for the synthesis of
Unexpected Novel Binding Mode of Pyrrolidine‐Based Aspartyl Protease Inhibitors: Design, Synthesis and Crystal Structure in Complex with HIV Protease
TLDR
It is surprising that the produced pyrrolidine derivatives achieve micromolar inhibition of HIV‐1 protease and cathepsin D and it suggests extraordinary potency of the new compound class.
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