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Classification and pharmacology of progestins.
Besides the natural progestin, progesterone, there are different classes of progestins, such as retroprogesterone, which need to be metabolized to become active compounds and have to be taken into account when medical treatment is considered. Expand
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The regional dimension is highlighted in this context because most renewable energy projects are carried out on local scale, based on the regional resource potential and vulnerability to climate change is very much determined by regional land use and the location of energy infrastructure. Expand
Clinical phase I dose escalation and pharmacokinetic study of high-dose chemotherapy with treosulfan and autologous peripheral blood stem cell transplantation in patients with advanced malignancies.
- M. Scheulen, R. Hilger, +12 authors S. Seeber
- Clinical cancer research : an official journal of…
- 1 November 2000
In consideration of antineoplastic activity and limited organ toxicity, inclusion of high-dose treosulfan in combination protocols with autologous peripheral blood stem cell transplantation seems worthwhile. Expand
Progestational effects of dydrogesterone in vitro, in vivo and on the human endometrium.
- A. Schindler
- 1 December 2009
Dydrogesterone has been used successfully to treat disorders related to absolute or relative progesterone deficiency and has beneficial effects in women with amenorrhea/oligomenorrhea, dysfunctional uterine bleeding and irregular cycles. Expand
Dienogest in long-term treatment of endometriosis
- A. Schindler
- International journal of women's health
- 6 July 2011
Dienogest showed a favorable safety and tolerability profile in these studies, with predictable adverse effects, high rates of patient compliance, and low withdrawal rates, including two studies characterizing dienogEST in long-term use. Expand
Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis
- P. Regidor, M. Regidor, +5 authors A. Schindler
- Gynecological endocrinology : the official…
- 1 January 2001
GnRH-agonists should be used as first-choice drugs in the treatment of endometriosis as the reduction of the r-AFS score in points was much more pronounced in the LAD group than in theLYN group, and the improvement in the symptoms of dysmenorrhea ,chronic pelvic pain and dyspareunia was also more pronouncedIn the L AD-treated group. Expand
Multicenter phase II study of oral capecitabine (Xeloda(")) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy.
- P. Reichardt, G. von Minckwitz, +9 authors H. Lück
- Annals of oncology : official journal of the…
- 1 August 2003
This study confirms that capecitabine achieves a high tumor control rate in heavily pretreated patients with metastatic breast cancer and should be considered the reference treatment in this setting based on consistently high efficacy and good tolerability. Expand
Reprint of Classification and pharmacology of progestins
There is a wide range of biological effects, which are different for the various progestins and have to be taken into account, when medical treatment is considered. Expand
Peritoneal endometriosis: validation of an in-vivo model.
This in-vivo model is a promising tool to test the effect of compounds such as different hormone agonists/antagonists or anti-angiogenic factors to develop new therapeutic concepts in endometriosis. Expand
Antiandrogenic progestins for treatment of signs of androgenisation and hormonal contraception.
- A. Schindler
- European journal of obstetrics, gynecology, and…
- 10 February 2004
Under long-term treatment a favourable effect on carbohydrate and lipid metabolism can be seen due to the antiandrogenic properties of the progestins, and these combinations also correct menstrual cycle disturbances and thus reduce the incidence of anaemia. Expand