Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
- M. Schwartz, A. Sipols, D. Figlewicz
- BiologyEndocrinology
- 1 June 1992
Fasting increases NPY biosynthesis along an arcuate nucleus-PVN pathway in the hypothalamus via a mechanism dependent on low insulin levels and suggests that insulin acts locally to inhibit hypothalamic NPY mRNA expression.
Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice.
- B. Ahrén, A. Scheurink
- Biology, MedicineEuropean Journal of Endocrinology
- 1 October 1998
It is shown that elevated leptin and FFA levels evolve after high-fat feeding in mice, in conjunction with evolvement of glucose intolerance and hyperglycemia, and suggesting leptin insensitivity.
NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior.
- A. Ammar, F. Sederholm, T. Saito, A. Scheurink, A. Johnson, P. Södersten
- Biology, PsychologyAmerican Journal of Physiology. Regulatory…
- 1 June 2000
It is suggested that NPY is not merely an orexigenic peptide, but one that directs attention toward food that diverts attention away from food toward alternate stimuli, and leptin may not be an anorexic peptides,but one that diverted attention toward alternate stimulus.
Neuroendocrine states and behavioral and physiological stress responses.
- B. Bohus, R. F. Benus, A. Steffens
- Psychology, BiologyProgress in Brain Research
- 1987
Hypothalamic, Metabolic, and Behavioral Responses to Pharmacological Inhibition of CNS Melanocortin Signaling in Rats
- T. Adage, A. Scheurink, G. van Dijk
- Biology, PsychologyJournal of Neuroscience
- 15 May 2001
Reduced activity of the CNS MC pathway promotes fat deposition via both food intake-dependent and -independent mechanisms and is found to occur despite a lack in neuropeptide expression responses in the neuroanatomical range selected across the arcuate and paraventricular hypothalamus.
Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats
- R. P. Barf, P. Meerlo, A. Scheurink
- Medicine, BiologyInternational Journal of Endocrinology
- 18 March 2010
Both moderate and severe disturbances of sleep markedly affect glucose homeostasis and body weight control in Wistar rats.
Neurobiology of hyperactivity and reward: Agreeable restlessness in Anorexia Nervosa
- A. Scheurink, G. Boersma, R. Nergårdh, P. Södersten
- Psychology, BiologyPhysiology and Behavior
- 14 July 2010
Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation.
- L. Benthem, K. Keizer, A. Scheurink
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 December 2000
The results are consistent with the concept that increased portal free fatty acid is involved in the induction of visceral obesity-related insulin resistance via activation of the HPA axis and sympathetic system.
Behavioral neuroendocrinology and treatment of anorexia nervosa
- P. Södersten, R. Nergårdh, C. Bergh, M. Zandian, A. Scheurink
- Psychology, BiologyFrontiers in neuroendocrinology (Print)
- 1 October 2008
Increased food intake and changes in metabolic hormones in response to chronic sleep restriction alternated with short periods of sleep allowance.
- R. P. Barf, T. Desprez, P. Meerlo, A. Scheurink
- Biology, PsychologyAmerican Journal of Physiology. Regulatory…
- 2012
Assessment of the metabolic consequences of a chronic sleep restriction protocol that modeled working weeks with restricted sleep time alternated by weekends with sleep allowance revealed that the alternation between periods of sleep restriction and sleep allowance leads to complex changes in food intake and body weight.
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