A. Scheffold

Publications170
h-index54
Citations11,738
Highly Influential Citations438
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Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this…
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
TLDR
The approach allows assessment of TH cells with a defined specificity for the combined quantitative and qualitative analysis of TH-cell immunity as well as for the isolation of specific TH cells for targeted cellular immunotherapies.
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
TLDR
It is shown that Th1 cells, but not Th2 cells, are able to bind to P- selectin and E-selectin, indicating that selective recruitment is an additional level of regulation for both effector function profile and character of a local immune response.
Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
TLDR
In vitro neutralization of IL‐2 mimics all effects of Treg, and the parakrine uptake of soluble mediators is proposed as a flexible mechanism to adapt Treg activity to the strength of the responder T cell reaction.
Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells
TLDR
The integrin αEβ7 can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments.
Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
TLDR
The present findings explain how IL-2 can play two disctinct roles in immune regulation and point to a hitherto largely unexplored spatiotemporal complexity of cytokine signaling.
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.
TLDR
The integrin alpha(E)beta(7), which recognizes epithelial cadherin, identifies the most potent subpopulation of regulatory CD25(+) T cells, which represents a unique subset in which high IL-2, IFN-gamma and T helper 2-cytokine production is linked with suppressive function.
Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection
TLDR
It is shown that small numbers of Teff cells have the ability to promote host protective immune responses, even in the presence of Treg cells, which are more potent suppressors than cells derived from naïve mice.
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo.
TLDR
Lack of suppression by Tregs deficient in E/P-selectin ligands demonstrates that immigration into inflamed sites is a prerequisite for the resolution of inflammatory reactions in vivo, and might have significant implications for anti-inflammatory therapies targeting recruitment mechanisms.
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