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Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of thisExpand
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P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
WHEN activated, T helper cells differentiate into one of two subsets, Th1 and Th2, characterized by distinct profiles of cytokine production. Th1 cells activate pro-inflammatory effector mechanismsExpand
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Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
The direct assessment of T helper (TH)-cell responses specific for antigens is essential to evaluate pathogenic and protective immunity. Presently, analysis and isolation of antigen-specific TH cellsExpand
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Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells
Regulatory CD25+CD4+ T cells are considered as important players in T cell homeostasis and self-tolerance. Here we report that the integrin αEβ7, which recognizes epithelial cadherin, identifies theExpand
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Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
Constitutive expression of CD25, the IL‐2 receptor α‐chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL‐2 has been implicated in theExpand
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Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
Cytokines are pleiotropic and readily diffusible messenger molecules, raising the question of how their action can be confined to specific target cells. The T cell cytokine interleukin-2 (IL-2) isExpand
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Autoregulation of Th1-mediated inflammation by twist1
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation-inducedExpand
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Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo.
Regulatory T cells (Tregs) play a fundamental role in the suppression of different immune responses; however, compartments at which they exert suppressive functions in vivo are unknown. Although manyExpand
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Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.
Regulatory CD25(+)CD4(+) T cells are considered as important players in T cell homeostasis and self-tolerance. Here we report that the integrin alpha(E)beta(7), which recognizes epithelial cadherin,Expand
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How alpha beta T cells deal with induced TCR alpha ablation.
On deletion of the gene encoding the constant region of the T cell antigen receptor (TCR)alpha chain in mature T cells by induced Cre-mediated recombination, the cells lose most of their TCR from theExpand
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