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Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.
TLDR
Excess body weight during midlife, including overweight, is associated with an increased risk of death in men and women aged 50 to 71 years old in the National Institutes of Health-AARP cohort. Expand
Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
TLDR
It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided. Expand
Statistical validation of intermediate endpoints for chronic diseases.
TLDR
A criterion due to Prentice for the statistical validation of intermediate endpoints for chronic disease, which involves examining in a cohort or intervention study whether an exposure or intervention effect, adjusted for the intermediate endpoint, is reduced to zero is discussed. Expand
Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN study.
TLDR
There was little underreporting of the percentage of energy from protein for men or women, and unbiased biomarkers of energy and protein intakes: doubly labeled water and urinary nitrogen have important implications for nutritional epidemiology and dietary surveillance. Expand
A Prospective Study of Red and Processed Meat Intake in Relation to Cancer Risk
TLDR
Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancer of the esophagus and liver. Expand
Structure of dietary measurement error: results of the OPEN biomarker study.
TLDR
Results suggest that the interpretation of findings from FFQ-based epidemiologic studies of diet-disease associations needs to be reevaluated because using the 24HR as a reference instrument can seriously underestimate true attenuation. Expand
A prospective study of diet quality and mortality in women.
TLDR
It is suggested that a dietary pattern characterized by consumption of foods recommended in current dietary guidelines is associated with decreased risk of mortality in women. Expand
Amount of time spent in sedentary behaviors and cause-specific mortality in US adults.
TLDR
Time spent in sedentary behaviors was positively associated with mortality, and participation in high levels of MVPA did not fully mitigate health risks associated with prolonged time watching television. Expand
A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.
TLDR
A positive association for red and processed meat intake and colorectal cancer is found; heme iron, nitrate/nitrite, and heterocyclic amines from meat may explain these associations. Expand
A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy.
TLDR
Factors that are associated most strongly with risk of advanced neoplasia are patient age and the number and size of prior adenomas. Expand
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