Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices.
Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus
Major depressive disorder
An overview of the current evidence of major depressive disorder, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment, is provided.
Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder.
- A. Etkin, Katherine E. Prater, A. Schatzberg, V. Menon, M. Greicius
- Psychology, BiologyArchives of General Psychiatry
- 1 December 2009
Evidence of an intra-amygdalar abnormality and engagement of a compensatory frontoparietal executive control network is found in GAD, consistent with cognitive theories of GAD.
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder.
- A. Etkin, Katherine E. Prater, F. Hoeft, V. Menon, A. Schatzberg
- PsychologyAmerican Journal of Psychiatry
- 1 May 2010
Patients with generalized anxiety disorder show significant deficits in the noninstructed and spontaneous regulation of emotional processing, which may open up avenues for novel treatments, such as by targeting the medial prefrontal cortex.
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
It is shown here that patients with depression can be subdivided into four neurophysiological subtypes defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks, which may be useful for identifying the individuals who are most likely to benefit from targeted neurostimulation therapies.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder.
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
Recommendations suggest that symptom ratings that measure all nine criterion symptom domains to define a major depressive episode are preferred as they provide a more certain ascertainment of remission.
Gender differences in treatment response to sertraline versus imipramine in chronic depression.
- S. Kornstein, A. Schatzberg, M. Keller
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 September 2000
Comparison of treatment response rates by menopausal status showed that premenopausal women responded significantly better to sertraline than to imipramine and that post menopausal women had similar rates of response to the two medications.