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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
TLDR
Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices. Expand
Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus
TLDR
The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression and suggest that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects. Expand
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder.
TLDR
Patients with generalized anxiety disorder show significant deficits in the noninstructed and spontaneous regulation of emotional processing, which may open up avenues for novel treatments, such as by targeting the medial prefrontal cortex. Expand
Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder.
TLDR
Evidence of an intra-amygdalar abnormality and engagement of a compensatory frontoparietal executive control network is found in GAD, consistent with cognitive theories of GAD. Expand
Major depressive disorder
TLDR
An overview of the current evidence of major depressive disorder, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment, is provided. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders.
TLDR
The potential role of CRH in circadian-dependent alerting, aside from its role in the stress response, is discussed, as is the role the HPA axis plays in secondary effects of primary sleep disorders. Expand
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
TLDR
Recommendations suggest that symptom ratings that measure all nine criterion symptom domains to define a major depressive episode are preferred as they provide a more certain ascertainment of remission. Expand
Gender differences in treatment response to sertraline versus imipramine in chronic depression.
TLDR
Comparison of treatment response rates by menopausal status showed that premenopausal women responded significantly better to sertraline than to imipramine and that post menopausal women had similar rates of response to the two medications. Expand
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
TLDR
It is shown here that patients with depression can be subdivided into four neurophysiological subtypes defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks, which may be useful for identifying the individuals who are most likely to benefit from targeted neurostimulation therapies. Expand
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