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Formalin-induced changes of NMDA receptor subunit expression in the spinal cord of the rat
The present data demonstrate adaptive changes in the NR subunit expression pattern in rat spinal cord due to formalin injection that significantly increased and decreased the proportion of NR2A and NR2C, respectively.
Value of superoxide dismutase for prevention of multiple organ failure after multiple trauma.
The results reveal an attenuation of organ failure after trauma, most likely by decreasing the release of inflammatory mediators and reduction of leukocyte-mediated organ injury.
Novel hepatoselective insulin analog: studies with a covalently linked thyroxyl-insulin complex in humans.
When injected subcutaneously into normal human subjects, Bl-T4-Ins is well tolerated, quickly absorbed, and highly protein bound, resulting in a long plasma halflife, and has the potential to provide more physiological insulin action than the insulin preparations currently used.
Crosslinked insulins: preparation, properties, and application.
The results of reduction/reoxidation studies with insulin derivatives containing irreversible and cleavable crosslinks are summarized and some results of tritium-labelling and of enzymatic degradation experiments with A1-B29-linked insulins are described.
Preparation and properties of covalently linked insulin dimers.
The synthesis of six isomeric insulin dimers, linked through selected amino groups of the monomers by a dicarboxylic acid, showed potencies between 1-60% that of insulin on a weight basis in stimulating lipogenesis in isolated fat cells.
Effects of covalently linked insulin dimers on receptor kinase activity and receptor down regulation
Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites
Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin
Biological action and fate of photoaffinity-labelled insulin-receptor complexes.
Time-dependence of biological activity induced by covalent insulin-receptor complexes in rat adipocytes.
- A. Schüttler, C. Diaconescu, D. Saunders, D. Brandenburg
- Biology, ChemistryThe Biochemical journal
- 15 November 1985
Lipogenesis in isolated adipocyte preparations is stimulated when photosensitive insulin derivatives are attached covalently to specific receptors. This response was compared quantitatively with that…