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p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis
ABSTRACT Bad is a critical regulatory component of the intrinsic cell death machinery that exerts its death-promoting effect upon heterodimerization with the antiapoptotic proteins Bcl-2 and Bcl-xL.Expand
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Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
To clarify the physiological role of Na+-d-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1−/− mice were generated and characterized phenotypically. After gavage of d-glucose, smallExpand
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HIV-1 Nef associated PAK and PI3-Kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
A highly conserved signaling property of Nef proteins encoded by human or simian immunodeficiency virus is the binding and activation of a PAK kinase whose function is unclear. Here we show thatExpand
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The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.
Glucose enters eucaryotic cells via 2 different types of membrane associated carrier proteins, the Na+-coupled glucose transporters (SGLT) and glucose transporter facilitators (GLUT). Three membersExpand
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Regulation of macropinocytosis by p21-activated kinase-1.
The process of macropinocytosis is an essential aspect of normal cell function, contributing to both growth and motile processes of cells. p21-activated kinases (PAKs) are targets for activated RacExpand
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The central melanocortin system directly controls peripheral lipid metabolism.
Disruptions of the melanocortin signaling system have been linked to obesity. We investigated a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of adiposity throughExpand
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Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration
Summary Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This process is thought to impair osteogenic and hematopoietic regeneration. Here we specify the cellularExpand
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Ghrelin action in the brain controls adipocyte metabolism.
Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine circuits involving the CNS. The CNS also directly regulates adipocyte metabolism, as we have shownExpand
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Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
The recent identification of several additional members of the family of sugar transport facilitators (gene symbol SLC2A, protein symbol GLUT) has created a heterogeneous and, in part, confusingExpand
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GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity*
GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1).Expand
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